Gene description for Ear11
Gene name eosinophil-associated, ribonuclease A family, member 11
Gene symbol Ear11
Other names/aliases EAR
ECP
R1
R7
Rnase3
Species Rattus norvegicus
 Database cross references - Ear11
ExoCarta ExoCarta_192264
Entrez Gene 192264
UniProt P70709  
 Ear11 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ear11
Molecular Function
    endonuclease activity GO:0004519 IBA
    nucleic acid binding GO:0003676 IEA
    ribonuclease activity GO:0004540 IBA
Biological Process
    defense response to Gram-positive bacterium GO:0050830 ISO
    antibacterial humoral response GO:0019731 ISO
    RNA phosphodiester bond hydrolysis GO:0090501 IBA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IBA
    innate immune response in mucosa GO:0002227 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Ear11 in exosomes
1
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ear11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ear11 is involved
No pathways found





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