Gene description for Ear11
Gene name eosinophil-associated, ribonuclease A family, member 11
Gene symbol Ear11
Other names/aliases EAR
ECP
R1
R7
Rnase3
Species Rattus norvegicus
 Database cross references - Ear11
ExoCarta ExoCarta_192264
Vesiclepedia VP_192264
Entrez Gene 192264
UniProt P70709  
 Ear11 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ear11
Molecular Function
    lipopolysaccharide binding GO:0001530 ISO
    nucleic acid binding GO:0003676 IEA
    endonuclease activity GO:0004519 IEA
    RNA nuclease activity GO:0004540 IBA
Biological Process
    innate immune response in mucosa GO:0002227 IBA
    innate immune response in mucosa GO:0002227 ISO
    chemotaxis GO:0006935 IBA
    innate immune response GO:0045087 ISO
    defense response to Gram-positive bacterium GO:0050830 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Ear11 in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ear11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ear11 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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