Gene description for Ear11
Gene name eosinophil-associated, ribonuclease A family, member 11
Gene symbol Ear11
Other names/aliases EAR
Species Rattus norvegicus
 Database cross references - Ear11
ExoCarta ExoCarta_192264
Entrez Gene 192264
UniProt P70709  
 Ear11 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ear11
Molecular Function
    endonuclease activity GO:0004519 IBA
    nucleic acid binding GO:0003676 IEA
    ribonuclease activity GO:0004540 IBA
Biological Process
    defense response to Gram-positive bacterium GO:0050830 ISO
    antibacterial humoral response GO:0019731 ISO
    RNA phosphodiester bond hydrolysis GO:0090501 IBA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IBA
    innate immune response in mucosa GO:0002227 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Ear11 in exosomes
Experiment ID 97
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ear11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ear11 is involved
No pathways found

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