Gene description for Acot2
Gene name acyl-CoA thioesterase 2
Gene symbol Acot2
Other names/aliases Mte1
Species Rattus norvegicus
 Database cross references - Acot2
ExoCarta ExoCarta_192272
Entrez Gene 192272
 Acot2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Acot2
Molecular Function
    acyl-CoA hydrolase activity GO:0047617 ISO
    receptor binding GO:0005102 ISO
    carboxylic ester hydrolase activity GO:0052689 IEA
    palmitoyl-CoA hydrolase activity GO:0016290 IDA
Biological Process
    response to hormone GO:0009725 IEP
    response to hypoxia GO:0001666 IDA
    acyl-CoA metabolic process GO:0006637 ISO
    long-chain fatty acid metabolic process GO:0001676 ISO
    response to epidermal growth factor GO:0070849 IEP
    response to nutrient levels GO:0031667 IEP
    response to drug GO:0042493 IEP
    very long-chain fatty acid catabolic process GO:0042760 IDA
    very long-chain fatty acid metabolic process GO:0000038 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified Acot2 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Acot2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acot2 is involved
No pathways found





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