Gene description for Ptp4a1
Gene name protein tyrosine phosphatase 4a1
Gene symbol Ptp4a1
Other names/aliases AA415290
AU019864
C130021B01
Prl-1
Species Mus musculus
 Database cross references - Ptp4a1
ExoCarta ExoCarta_19243
Vesiclepedia VP_19243
Entrez Gene 19243
UniProt Q63739  
 Ptp4a1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ptp4a1
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 ISO
    protein tyrosine phosphatase activity GO:0004725 TAS
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    positive regulation of cell migration GO:0030335 IBA
    positive regulation of cell migration GO:0030335 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    endosome GO:0005768 TAS
    early endosome GO:0005769 IEA
    endoplasmic reticulum GO:0005783 IEA
    spindle GO:0005819 IEA
    plasma membrane GO:0005886 TAS
    cytoplasmic side of plasma membrane GO:0009898 ISO
 Experiment description of studies that identified Ptp4a1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ptp4a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Gnl1 14670
Co-fractionation Mus musculus
2 Mchr1  
Proximity Label-MS Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ptp4a1 is involved
No pathways found





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