Gene description for Ptp4a1
Gene name protein tyrosine phosphatase 4a1
Gene symbol Ptp4a1
Other names/aliases AA415290
AU019864
C130021B01
Prl-1
Species Mus musculus
 Database cross references - Ptp4a1
ExoCarta ExoCarta_19243
Entrez Gene 19243
UniProt Q63739  
 Ptp4a1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ptp4a1
Molecular Function
    prenylated protein tyrosine phosphatase activity GO:0004727 TAS
    protein tyrosine phosphatase activity GO:0004725 ISO
    phosphatase activity GO:0016791 IEA
    phosphoprotein phosphatase activity GO:0004721 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    peptidyl-tyrosine dephosphorylation GO:0035335 ISO
    protein dephosphorylation GO:0006470 IEA
    dephosphorylation GO:0016311 IEA
    multicellular organismal development GO:0007275 IEA
    positive regulation of cell migration GO:0030335 IDA
    cell cycle GO:0007049 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum GO:0005783 IEA
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 TAS
    endosome GO:0005768 TAS
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Ptp4a1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ptp4a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptp4a1 is involved
No pathways found





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