Gene description for Ptp4a2
Gene name protein tyrosine phosphatase 4a2
Gene symbol Ptp4a2
Other names/aliases Prl-2
Species Mus musculus
 Database cross references - Ptp4a2
ExoCarta ExoCarta_19244
Vesiclepedia VP_19244
Entrez Gene 19244
UniProt O70274  
 Ptp4a2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ptp4a2
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    enzyme inhibitor activity GO:0004857 IDA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    early endosome GO:0005769 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Ptp4a2 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ptp4a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml
 Pathways in which Ptp4a2 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
RAB geranylgeranylation IEA Reactome





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