Gene description for Rab12
Gene name RAB12, member RAS oncogene family
Gene symbol Rab12
Other names/aliases 2900054P15Rik
AW555448
C77700
Species Mus musculus
 Database cross references - Rab12
ExoCarta ExoCarta_19328
Entrez Gene 19328
UniProt P35283  
 Rab12 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rab12
Molecular Function
    GDP binding GO:0019003 ISO
    nucleotide binding GO:0000166 IEA
    GTP binding GO:0005525 IEA
    GTPase activity GO:0003924 IBA
Biological Process
    autophagy GO:0006914 IEA
    positive regulation of macroautophagy GO:0016239 IMP
    regulation of exocytosis GO:0017157 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
    cellular protein catabolic process GO:0044257 IMP
    endosome to lysosome transport GO:0008333 IMP
    protein transport GO:0015031 IEA
    transport GO:0006810 IEA
    vesicle docking involved in exocytosis GO:0006904 IBA
    protein localization to plasma membrane GO:0072659 IBA
    Rab protein signal transduction GO:0032482 IBA
    intracellular protein transport GO:0006886 IBA
    protein secretion GO:0009306 IBA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IEA
    secretory granule GO:0030141 ISO
    cell GO:0005623 IMP
    Golgi apparatus GO:0005794 IBA
    intracellular GO:0005622 IMP
    recycling endosome membrane GO:0055038 IDA
    autophagosome GO:0005776 IDA
    membrane GO:0016020 IEA
    endosome GO:0005768 IEA
    lysosome GO:0005764 IDA
 Experiment description of studies that identified Rab12 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rab12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab12 is involved
No pathways found





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