Gene description for Rab23
Gene name RAB23, member RAS oncogene family
Gene symbol Rab23
Other names/aliases AW545388
opb
opb2
Species Mus musculus
 Database cross references - Rab23
ExoCarta ExoCarta_19335
Vesiclepedia VP_19335
Entrez Gene 19335
 Rab23 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rab23
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    GTP binding GO:0005525 IEA
Biological Process
    autophagosome assembly GO:0000045 IBA
    autophagosome assembly GO:0000045 ISO
    autophagosome assembly GO:0000045 ISS
    neural tube closure GO:0001843 IMP
    neural tube closure GO:0001843 IMP
    proteolysis GO:0006508 IMP
    intracellular protein transport GO:0006886 IBA
    cellular defense response GO:0006968 ISO
    cellular defense response GO:0006968 ISS
    signal transduction GO:0007165 IMP
    nervous system development GO:0007399 IMP
    regulation of smoothened signaling pathway GO:0008589 IGI
    protein transport GO:0015031 IEA
    spinal cord dorsal/ventral patterning GO:0021513 IGI
    spinal cord dorsal/ventral patterning GO:0021513 IMP
    dorsal/ventral neural tube patterning GO:0021904 IMP
    negative regulation of protein import into nucleus GO:0042308 ISO
    negative regulation of protein import into nucleus GO:0042308 ISS
    embryonic digit morphogenesis GO:0042733 IMP
    negative regulation of proteolysis GO:0045861 IMP
    GTP metabolic process GO:0046039 ISO
    GTP metabolic process GO:0046039 ISS
    cilium assembly GO:0060271 ISO
    craniofacial suture morphogenesis GO:0097094 ISO
    craniofacial suture morphogenesis GO:0097094 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    autophagosome GO:0005776 IBA
    autophagosome GO:0005776 ISO
    autophagosome GO:0005776 ISS
    centrosome GO:0005813 ISO
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    endosome membrane GO:0010008 IBA
    endosome membrane GO:0010008 IDA
    endomembrane system GO:0012505 IBA
    cell junction GO:0030054 ISO
    phagocytic vesicle membrane GO:0030670 IEA
    phagocytic vesicle GO:0045335 ISO
    phagocytic vesicle GO:0045335 ISS
 Experiment description of studies that identified Rab23 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rab23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rab23 is involved
No pathways found





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