Gene description for EFNB2
Gene name ephrin-B2
Gene symbol EFNB2
Other names/aliases EPLG5
Species Homo sapiens
 Database cross references - EFNB2
ExoCarta ExoCarta_1948
Entrez Gene 1948
HGNC 3227
MIM 600527
UniProt P52799  
 EFNB2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for EFNB2
Molecular Function
    ephrin receptor binding GO:0046875 IPI
    protein binding GO:0005515 IPI
Biological Process
    lymph vessel development GO:0001945 IEA
    axon guidance GO:0007411 TAS
    viral process GO:0016032 IEA
    cell-cell signaling GO:0007267 TAS
    regulation of chemotaxis GO:0050920 IDA
    ephrin receptor signaling pathway GO:0048013 TAS
    organ morphogenesis GO:0009887 IEA
    blood vessel morphogenesis GO:0048514 IBA
    anatomical structure morphogenesis GO:0009653 TAS
    cell adhesion GO:0007155 IDA
    cell migration involved in sprouting angiogenesis GO:0002042 IDA
    positive regulation of cardiac muscle cell differentiation GO:2000727 ISS
    negative regulation of keratinocyte proliferation GO:0010839 IEA
Subcellular Localization
    focal adhesion GO:0005925 IDA
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified EFNB2 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for EFNB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPHA4 2043
Invivo Homo sapiens
2 EPHB2 2048
Invivo Homo sapiens
Invitro Homo sapiens
3 EPHA3 2042
Reconstituted Complex Homo sapiens
4 EPHB1 2047
Invivo Homo sapiens
Invitro Homo sapiens
5 Ephb1  
Reconstituted Complex Rattus norvegicus
6 EPHB4 2050
Invivo Homo sapiens
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