Gene description for Rfx3
Gene name regulatory factor X, 3 (influences HLA class II expression)
Gene symbol Rfx3
Other names/aliases C230093O12Rik
MRFX3
Species Mus musculus
 Database cross references - Rfx3
ExoCarta ExoCarta_19726
Entrez Gene 19726
UniProt P48381  
 Rfx3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rfx3
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IBA
    transcription regulatory region DNA binding GO:0044212 ISO
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IMP
    cilium-dependent cell motility GO:0060285 IMP
    cell differentiation GO:0030154 IEA
    cell maturation GO:0048469 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 IMP
    transcription, DNA-templated GO:0006351 IMP
    regulation of insulin secretion GO:0050796 IMP
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    type B pancreatic cell maturation GO:0072560 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    cilium assembly GO:0042384 IMP
    multicellular organismal development GO:0007275 IEA
    endocrine pancreas development GO:0031018 IMP
    determination of left/right symmetry GO:0007368 IMP
    positive regulation of type B pancreatic cell development GO:2000078 IMP
Subcellular Localization
    nuclear chromatin GO:0000790 ISO
    nucleus GO:0005634 IBA
    transcription factor complex GO:0005667 IC
 Experiment description of studies that identified Rfx3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rfx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rfx3 is involved
No pathways found





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