Gene description for Serpinb3a
Gene name serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
Gene symbol Serpinb3a
Other names/aliases 1110001H02Rik
1110013A16Rik
Scca2
Serpinb4
Sqn5
Species Mus musculus
 Database cross references - Serpinb3a
ExoCarta ExoCarta_20248
Entrez Gene 20248
 Serpinb3a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Serpinb3a
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 ISO
    protease binding GO:0002020 ISO
    enzyme binding GO:0019899 ISO
Biological Process
    negative regulation of peptidase activity GO:0010466 ISO
    negative regulation of endopeptidase activity GO:0010951 ISO
    protection from natural killer cell mediated cytotoxicity GO:0042270 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 IBA
    intracellular GO:0005622 ISO
 Experiment description of studies that identified Serpinb3a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Serpinb3a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serpinb3a is involved
No pathways found





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