Gene description for Cx3cl1
Gene name chemokine (C-X3-C motif) ligand 1
Gene symbol Cx3cl1
Other names/aliases AB030188
Species Mus musculus
 Database cross references - Cx3cl1
ExoCarta ExoCarta_20312
Entrez Gene 20312
UniProt O35188  
 Cx3cl1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cx3cl1
Molecular Function
    cytokine activity GO:0005125 IEA
    chemokine activity GO:0008009 ISO
Biological Process
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    lymphocyte chemotaxis GO:0048247 IDA
    positive regulation of calcium-independent cell-cell adhesion GO:0051041 ISO
    negative regulation of vasoconstriction GO:0045906 ISO
    positive regulation of transforming growth factor beta1 production GO:0032914 IMP
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of macrophage chemotaxis GO:0010759 ISO
    macrophage chemotaxis GO:0048246 IMP
    immune response GO:0006955 IEA
    positive regulation of neuroblast proliferation GO:0002052 ISO
    positive regulation of angiogenesis GO:0045766 IMP
    regulation of inhibitory postsynaptic membrane potential GO:0060080 ISO
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IDA
    chemotaxis GO:0006935 ISO
    wound healing GO:0042060 IMP
    neutrophil chemotaxis GO:0030593 IDA
    angiogenesis involved in wound healing GO:0060055 IMP
    microglial cell activation GO:0001774 ISO
    cell adhesion GO:0007155 IEA
    platelet activation GO:0030168 ISO
    cytokine-mediated signaling pathway GO:0019221 IMP
    leukocyte adhesive activation GO:0050902 IEA
    negative regulation of cytokine secretion GO:0050710 ISO
    cell chemotaxis GO:0060326 ISO
    positive regulation of cell adhesion GO:0045785 ISO
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IEA
    extracellular region GO:0005576 ISO
    integral component of membrane GO:0016021 ISO
    extracellular space GO:0005615 IEA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IEA
    cell projection GO:0042995 ISO
 Experiment description of studies that identified Cx3cl1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cx3cl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cx3cl1 is involved
Chemokine receptors bind chemokines IEA Reactome

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