Gene description for Cx3cl1
Gene name	chemokine (C-X3-C motif) ligand 1
Gene symbol	Cx3cl1
Other names/aliases	AB030188 ABCD-3 AI848747 CX3C Cxc3 D8Bwg0439e Scyd1
Species	Mus musculus
Database cross references - Cx3cl1
ExoCarta	ExoCarta_20312
Vesiclepedia	VP_20312
Entrez Gene	20312
UniProt	O35188
Cx3cl1 identified in sEVs derived from the following tissue/cell type
Fibroblasts	23260141

Gene ontology annotations for Cx3cl1

Molecular Function     integrin binding GO:0005178 ISO     integrin binding GO:0005178 ISS     chemokine activity GO:0008009 IBA     chemokine activity GO:0008009 ISO     CX3C chemokine receptor binding GO:0031737 IDA     CX3C chemokine receptor binding GO:0031737 ISO     CX3C chemokine receptor binding GO:0031737 ISS     chemoattractant activity GO:0042056 IEA     chemoattractant activity GO:0042056 ISO     CXCR1 chemokine receptor binding GO:0045237 IEA     CXCR1 chemokine receptor binding GO:0045237 ISO     CCR chemokine receptor binding GO:0048020 IBA Biological Process     microglial cell activation GO:0001774 ISO     positive regulation of neuroblast proliferation GO:0002052 ISO     leukocyte migration involved in inflammatory response GO:0002523 ISO     leukocyte migration involved in inflammatory response GO:0002523 ISS     response to ischemia GO:0002931 ISO     chemotaxis GO:0006935 ISO     chemotaxis GO:0006935 ISS     inflammatory response GO:0006954 IBA     immune response GO:0006955 IEA     cell adhesion GO:0007155 IEA     cell adhesion GO:0007155 ISO     G protein-coupled receptor signaling pathway GO:0007186 ISO     positive regulation of cell population proliferation GO:0008284 IEA     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of macrophage chemotaxis GO:0010759 ISO     positive regulation of neuron projection development GO:0010976 ISO     cytokine-mediated signaling pathway GO:0019221 IMP     positive regulation of cell migration GO:0030335 IBA     positive regulation of cell migration GO:0030335 ISO     negative regulation of cell migration GO:0030336 IEA     negative regulation of cell migration GO:0030336 ISO     neutrophil chemotaxis GO:0030593 IDA     regulation of lipopolysaccharide-mediated signaling pathway GO:0031664 IEA     regulation of lipopolysaccharide-mediated signaling pathway GO:0031664 ISO     positive regulation of actin filament bundle assembly GO:0032233 IEA     positive regulation of actin filament bundle assembly GO:0032233 ISO     negative regulation of interleukin-1 alpha production GO:0032690 ISO     negative regulation of tumor necrosis factor production GO:0032720 IEA     negative regulation of tumor necrosis factor production GO:0032720 ISO     positive regulation of transforming growth factor beta1 production GO:0032914 IMP     integrin activation GO:0033622 ISO     integrin activation GO:0033622 ISS     autocrine signaling GO:0035425 ISO     wound healing GO:0042060 IMP     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of MAPK cascade GO:0043410 IEA     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of cell adhesion GO:0045785 ISO     negative regulation of vasoconstriction GO:0045906 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     eosinophil chemotaxis GO:0048245 IBA     lymphocyte chemotaxis GO:0048247 IDA     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     positive regulation of inflammatory response GO:0050729 IEA     positive chemotaxis GO:0050918 IEA     positive chemotaxis GO:0050918 ISO     positive regulation of calcium-independent cell-cell adhesion GO:0051041 IEA     positive regulation of calcium-independent cell-cell adhesion GO:0051041 ISO     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     angiogenesis involved in wound healing GO:0060055 IMP     inhibitory postsynaptic potential GO:0060080 ISO     cell chemotaxis GO:0060326 ISO     microglial cell proliferation GO:0061518 IEA     microglial cell proliferation GO:0061518 ISO     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA     neuron cellular homeostasis GO:0070050 ISO     chemokine-mediated signaling pathway GO:0070098 IBA     chemokine-mediated signaling pathway GO:0070098 IEA     chemokine-mediated signaling pathway GO:0070098 ISO     cellular response to tumor necrosis factor GO:0071356 ISO     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IDA     cell-cell adhesion GO:0098609 ISO     negative regulation of hippocampal neuron apoptotic process GO:0110091 IEA     negative regulation of hippocampal neuron apoptotic process GO:0110091 ISO     negative regulation of glutamate receptor signaling pathway GO:1900450 ISO     positive regulation of I-kappaB phosphorylation GO:1903721 ISO     negative regulation of microglial cell activation GO:1903979 ISO     positive regulation of microglial cell migration GO:1904141 IEA     positive regulation of microglial cell migration GO:1904141 ISO     negative regulation of apoptotic signaling pathway GO:2001234 ISO     negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IDA Subcellular Localization     extracellular region GO:0005576 ISO     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IEA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISS     cell surface GO:0009986 ISO     membrane GO:0016020 ISO     cell projection GO:0042995 ISO     neuron projection GO:0043005 IDA     neuron projection GO:0043005 ISO     neuronal cell body GO:0043025 IDA     neuronal cell body GO:0043025 ISO     cell body GO:0044297 IDA     perinuclear region of cytoplasm GO:0048471 ISO