Gene description for Sema4d
Gene name	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Gene symbol	Sema4d
Other names/aliases	CD100 Semacl2 Semaj Semcl2 coll-4
Species	Mus musculus
Database cross references - Sema4d
ExoCarta	ExoCarta_20354
Vesiclepedia	VP_20354
Entrez Gene	20354
UniProt	O09126
Sema4d identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Sema4d

Molecular Function     transmembrane signaling receptor activity GO:0004888 ISO     transmembrane signaling receptor activity GO:0004888 ISS     signaling receptor binding GO:0005102 IPI     signaling receptor binding GO:0005102 ISO     protein binding GO:0005515 IPI     semaphorin receptor binding GO:0030215 IBA     semaphorin receptor binding GO:0030215 IPI     semaphorin receptor binding GO:0030215 ISO     signaling receptor activity GO:0038023 ISO     neuropilin binding GO:0038191 IBA     identical protein binding GO:0042802 ISO     chemorepellent activity GO:0045499 IBA     receptor ligand activity GO:0048018 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     neural crest cell migration GO:0001755 IBA     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of protein phosphorylation GO:0001934 ISS     negative regulation of cell adhesion GO:0007162 ISO     negative regulation of cell adhesion GO:0007162 ISS     axonogenesis GO:0007409 IDA     axonogenesis GO:0007409 IGI     axon guidance GO:0007411 IBA     regulation of cell shape GO:0008360 ISO     regulation of cell shape GO:0008360 ISS     positive regulation of cell migration GO:0030335 IBA     positive regulation of cell migration GO:0030335 IDA     positive regulation of cell migration GO:0030335 ISO     regulation of cell projection organization GO:0031344 ISO     regulation of cell projection organization GO:0031344 ISS     positive regulation of Rho protein signal transduction GO:0035025 IMP     positive regulation of GTPase activity GO:0043547 ISO     ossification involved in bone maturation GO:0043931 IMP     ossification involved in bone maturation GO:0043931 ISO     negative regulation of osteoblast differentiation GO:0045668 IMP     positive regulation of collateral sprouting GO:0048672 ISO     positive regulation of collateral sprouting GO:0048672 ISS     regulation of dendrite morphogenesis GO:0048814 ISO     regulation of dendrite morphogenesis GO:0048814 ISS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IDA     positive regulation of axonogenesis GO:0050772 IDA     positive regulation of axonogenesis GO:0050772 IGI     negative chemotaxis GO:0050919 IBA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     regulation of synapse assembly GO:0051963 IDA     regulation of synapse assembly GO:0051963 IMP     bone trabecula morphogenesis GO:0061430 IMP     leukocyte aggregation GO:0070486 ISO     leukocyte aggregation GO:0070486 ISS     semaphorin-plexin signaling pathway GO:0071526 IBA     semaphorin-plexin signaling pathway GO:0071526 IMP     semaphorin-plexin signaling pathway GO:0071526 ISO     semaphorin-plexin signaling pathway GO:0071526 ISS     positive regulation of inhibitory synapse assembly GO:1905704 IDA     positive regulation of inhibitory synapse assembly GO:1905704 IMP Subcellular Localization     semaphorin receptor complex GO:0002116 IMP     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     membrane GO:0016020 TAS     postsynaptic membrane GO:0045211 IEA     GABA-ergic synapse GO:0098982 IDA     GABA-ergic synapse GO:0098982 IMP