Gene description for Siah1b
Gene name seven in absentia 1B
Gene symbol Siah1b
Other names/aliases AA960570
Sinh1b
siah-1b
Species Mus musculus
 Database cross references - Siah1b
ExoCarta ExoCarta_20438
Vesiclepedia VP_20438
Entrez Gene 20438
UniProt Q06985  
 Siah1b identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Siah1b
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISO
    ubiquitin-protein transferase activity GO:0004842 ISS
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    ubiquitin conjugating enzyme binding GO:0031624 IBA
    identical protein binding GO:0042802 ISO
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISO
    ubiquitin protein ligase activity GO:0061630 TAS
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    protein ubiquitination GO:0016567 IEA
    protein catabolic process GO:0030163 ISO
    protein destabilization GO:0031648 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    neuron apoptotic process GO:0051402 ISO
    neuron apoptotic process GO:0051402 ISS
    canonical Wnt signaling pathway GO:0060070 ISO
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    early endosome GO:0005769 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    beta-catenin destruction complex GO:0030877 ISO
 Experiment description of studies that identified Siah1b in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Siah1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Usp7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Siah1b is involved
No pathways found





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