Gene description for Siah1b
Gene name seven in absentia 1B
Gene symbol Siah1b
Other names/aliases AA960570
Sinh1b
siah-1b
Species Mus musculus
 Database cross references - Siah1b
ExoCarta ExoCarta_20438
Entrez Gene 20438
UniProt Q06985  
 Siah1b identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Siah1b
Molecular Function
    protein-glutamic acid ligase activity GO:0070739 IEA
    metal ion binding GO:0046872 IEA
    protein-glycine ligase activity GO:0070735 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    protein-glycine ligase activity, elongating GO:0070737 IEA
    ubiquitin-protein transferase activity GO:0004842 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    ubiquitin protein ligase activity GO:0061630 TAS
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    zinc ion binding GO:0008270 IEA
    ligase activity GO:0016874 IEA
    protein-glycine ligase activity, initiating GO:0070736 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    protein ubiquitination GO:0016567 TAS
    multicellular organismal development GO:0007275 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Siah1b in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Siah1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Siah1b is involved
No pathways found





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