Gene description for Six3
Gene name sine oculis-related homeobox 3
Gene symbol Six3
Other names/aliases E130112M24Rik
Six3a
Six3alpha
Six3b
Six3beta
Species Mus musculus
 Database cross references - Six3
ExoCarta ExoCarta_20473
Vesiclepedia VP_20473
Entrez Gene 20473
UniProt Q62233  
 Six3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Six3
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    transcription corepressor binding GO:0001222 IPI
    transcription corepressor binding GO:0001222 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IPI
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    eye development GO:0001654 IBA
    eye development GO:0001654 IDA
    eye development GO:0001654 ISO
    epithelial cell maturation GO:0002070 IMP
    lens development in camera-type eye GO:0002088 IDA
    optic vesicle morphogenesis GO:0003404 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    protein import into nucleus GO:0006606 IDA
    brain development GO:0007420 IBA
    brain development GO:0007420 IMP
    gonad development GO:0008406 IGI
    proximal/distal axis specification GO:0009946 IDA
    neuroblast differentiation GO:0014016 IMP
    diencephalon development GO:0021536 IGI
    telencephalon development GO:0021537 IMP
    telencephalon development GO:0021537 IMP
    forebrain anterior/posterior pattern specification GO:0021797 IGI
    forebrain anterior/posterior pattern specification GO:0021797 IMP
    forebrain dorsal/ventral pattern formation GO:0021798 ISO
    forebrain dorsal/ventral pattern formation GO:0021798 ISS
    cell proliferation in forebrain GO:0021846 IMP
    telencephalon regionalization GO:0021978 IMP
    pituitary gland development GO:0021983 IGI
    pituitary gland development GO:0021983 IMP
    negative regulation of Wnt signaling pathway GO:0030178 IMP
    thyroid gland development GO:0030878 IGI
    multicellular organism growth GO:0035264 IGI
    regulation of cell population proliferation GO:0042127 IMP
    camera-type eye development GO:0043010 IGI
    negative regulation of neuron differentiation GO:0045665 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    circadian behavior GO:0048512 IMP
    lens induction in camera-type eye GO:0060235 IMP
    regulation of neural retina development GO:0061074 IMP
    lens fiber cell differentiation GO:0070306 IDA
    neuroblast migration GO:0097402 IMP
    regulation of cell cycle phase transition GO:1901987 IDA
    regulation of neuroblast proliferation GO:1902692 IMP
    apoptotic process involved in development GO:1902742 IMP
    lens fiber cell apoptotic process GO:1990086 IDA
    regulation of neural precursor cell proliferation GO:2000177 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    transcription regulator complex GO:0005667 IBA
 Experiment description of studies that identified Six3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Six3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tle4  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
2 Aes  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
3 Eya1  
Affinity Capture-Western Mus musculus
4 gro  
Reconstituted Complex Drosophila melanogaster
Affinity Capture-Western Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Six3 is involved
No pathways found





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