Gene description for Six3
Gene name sine oculis-related homeobox 3
Gene symbol Six3
Other names/aliases E130112M24Rik
Six3a
Six3alpha
Six3b
Six3beta
Species Mus musculus
 Database cross references - Six3
ExoCarta ExoCarta_20473
Entrez Gene 20473
UniProt Q62233  
 Six3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Six3
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    histone deacetylase binding GO:0042826 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IDA
    sequence-specific DNA binding GO:0043565 IDA
    receptor binding GO:0005102 ISO
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IDA
    transcription corepressor binding GO:0001222 ISO
Biological Process
    regulation of neural retina development GO:0061074 IMP
    camera-type eye development GO:0043010 IGI
    proximal/distal axis specification GO:0009946 IDA
    cell proliferation in forebrain GO:0021846 IMP
    regulation of neuroblast proliferation GO:1902692 IMP
    diencephalon development GO:0021536 IGI
    eye development GO:0001654 ISO
    transcription from RNA polymerase II promoter GO:0006366 IDA
    negative regulation of Wnt signaling pathway GO:0030178 IMP
    neuroblast migration GO:0097402 IMP
    multicellular organismal development GO:0007275 IEA
    optic vesicle morphogenesis GO:0003404 IDA
    forebrain anterior/posterior pattern specification GO:0021797 IMP
    lens induction in camera-type eye GO:0060235 IMP
    regulation of cell cycle phase transition GO:1901987 IDA
    telencephalon development GO:0021537 IMP
    pituitary gland development GO:0021983 IMP
    circadian behavior GO:0048512 IMP
    neuroblast differentiation GO:0014016 IMP
    epithelial cell maturation GO:0002070 IMP
    negative regulation of neuron differentiation GO:0045665 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    apoptotic process involved in development GO:1902742 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    brain development GO:0007420 IMP
    lens fiber cell apoptotic process GO:1990086 IDA
    protein import into nucleus, translocation GO:0000060 IDA
    regulation of neural precursor cell proliferation GO:2000177 IDA
    regulation of cell proliferation GO:0042127 IMP
    forebrain dorsal/ventral pattern formation GO:0021798 ISO
    protein import into nucleus GO:0006606 IDA
    lens fiber cell differentiation GO:0070306 IDA
    transcription, DNA-templated GO:0006351 IEA
    telencephalon regionalization GO:0021978 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    lens development in camera-type eye GO:0002088 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Six3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Six3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tle4  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
2 Aes  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
3 gro  
Reconstituted Complex 7227
Affinity Capture-Western 7227
View the network image/svg+xml
 Pathways in which Six3 is involved
No pathways found





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