Gene description for Slc1a5
Gene name solute carrier family 1 (neutral amino acid transporter), member 5
Gene symbol Slc1a5
Other names/aliases AAAT
ASCT2
ATBO
M7V1
M7VS1
R16
RDRC
Slc1a7
Species Mus musculus
 Database cross references - Slc1a5
ExoCarta ExoCarta_20514
Vesiclepedia VP_20514
Entrez Gene 20514
 Slc1a5 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc1a5
Molecular Function
    L-serine transmembrane transporter activity GO:0015194 ISO
    neutral amino acid transmembrane transporter activity GO:0015175 IDA
    sodium:dicarboxylate symporter activity GO:0017153 IEA
    symporter activity GO:0015293 IEA
    amino acid transmembrane transporter activity GO:0015171 ISO
Biological Process
    L-serine transport GO:0015825 ISO
    amino acid transmembrane transport GO:0003333 ISO
    extracellular amino acid transport GO:0006860 ISO
    dicarboxylic acid transport GO:0006835 IEA
    transport GO:0006810 IEA
    L-alpha-amino acid transmembrane transport GO:1902475 ISO
    cation transmembrane transport GO:0098655 ISO
    neutral amino acid transport GO:0015804 IDA
Subcellular Localization
    plasma membrane GO:0005886 ISO
    Golgi apparatus GO:0005794 ISO
    membrane GO:0016020 ISO
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 ISO
 Experiment description of studies that identified Slc1a5 in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
EV Biophysical techniques
CD81|FLOT1
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc1a5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc1a5 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here