Gene description for Slc1a5
Gene name solute carrier family 1 (neutral amino acid transporter), member 5
Gene symbol Slc1a5
Other names/aliases AAAT
ASCT2
ATBO
M7V1
M7VS1
R16
RDRC
Slc1a7
Species Mus musculus
 Database cross references - Slc1a5
ExoCarta ExoCarta_20514
Vesiclepedia VP_20514
Entrez Gene 20514
 Slc1a5 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc1a5
Molecular Function
    neutral L-amino acid transmembrane transporter activity GO:0015175 IBA
    neutral L-amino acid transmembrane transporter activity GO:0015175 IDA
    L-aspartate transmembrane transporter activity GO:0015183 IBA
    L-aspartate transmembrane transporter activity GO:0015183 IDA
    L-aspartate transmembrane transporter activity GO:0015183 ISO
    L-glutamine transmembrane transporter activity GO:0015186 ISO
    L-glutamine transmembrane transporter activity GO:0015186 ISS
    L-serine transmembrane transporter activity GO:0015194 ISO
    symporter activity GO:0015293 IEA
    antiporter activity GO:0015297 IEA
    antiporter activity GO:0015297 ISO
    ligand-gated channel activity GO:0022834 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    glutamine transport GO:0006868 ISO
    glutamine transport GO:0006868 ISS
    glutamine secretion GO:0010585 ISO
    acidic amino acid transport GO:0015800 IEA
    neutral amino acid transport GO:0015804 ISO
    L-serine transport GO:0015825 ISO
    erythrocyte differentiation GO:0030218 ISO
    protein homotrimerization GO:0070207 ISO
    protein homotrimerization GO:0070207 ISS
    L-aspartate import across plasma membrane GO:0140009 IBA
    L-aspartate import across plasma membrane GO:0140009 IDA
    L-aspartate import across plasma membrane GO:0140009 ISO
    transport across blood-brain barrier GO:0150104 IDA
    L-glutamine import across plasma membrane GO:1903803 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    basal plasma membrane GO:0009925 IDA
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    melanosome GO:0042470 IEA
 Experiment description of studies that identified Slc1a5 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc1a5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Slc1a5 is involved
No pathways found





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