Gene description for Slc2a1
Gene name solute carrier family 2 (facilitated glucose transporter), member 1
Gene symbol Slc2a1
Other names/aliases Glut-1
Glut1
Species Mus musculus
 Database cross references - Slc2a1
ExoCarta ExoCarta_20525
Entrez Gene 20525
UniProt P17809  
 Slc2a1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Slc2a1
Molecular Function
    xenobiotic transporter activity GO:0042910 ISO
    kinase binding GO:0019900 ISO
    substrate-specific transmembrane transporter activity GO:0022891 IEA
    protein self-association GO:0043621 ISO
    transporter activity GO:0005215 IEA
    glucose transmembrane transporter activity GO:0005355 ISO
    D-glucose transmembrane transporter activity GO:0055056 ISO
    identical protein binding GO:0042802 ISO
    transmembrane transporter activity GO:0022857 IEA
    dehydroascorbic acid transporter activity GO:0033300 ISO
    protein binding GO:0005515 IPI
    sugar:proton symporter activity GO:0005351 IBA
Biological Process
    carbohydrate transport GO:0008643 IEA
    protein complex assembly GO:0006461 ISO
    glucose transport GO:0015758 ISO
    xenobiotic transport GO:0042908 ISO
    cellular response to glucose starvation GO:0042149 IDA
    transmembrane transport GO:0055085 IEA
    transport GO:0006810 IEA
    glucose import GO:0046323 IBA
    cation transmembrane transport GO:0098655 IBA
    proton transport GO:0015992 IBA
    hexose transmembrane transport GO:0035428 IDA
    dehydroascorbic acid transport GO:0070837 ISO
Subcellular Localization
    midbody GO:0030496 ISO
    cell-cell junction GO:0005911 ISO
    intracellular GO:0005622 IDA
    vesicle GO:0031982 IDA
    blood microparticle GO:0072562 ISO
    caveola GO:0005901 ISO
    cytosol GO:0005829 IDA
    female pronucleus GO:0001939 IDA
    plasma membrane GO:0005886 ISO
    integral component of plasma membrane GO:0005887 ISO
    membrane GO:0016020 IDA
    cortical actin cytoskeleton GO:0030864 ISO
    cytoplasm GO:0005737 ISO
    basolateral plasma membrane GO:0016323 IDA
    extracellular exosome GO:0070062 ISO
    integral component of membrane GO:0016021 IEA
    membrane raft GO:0045121 IDA
 Experiment description of studies that identified Slc2a1 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 214
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 215
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 216
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc2a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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