Gene description for Slc31a1
Gene name solute carrier family 31, member 1
Gene symbol Slc31a1
Other names/aliases 4930445G01Rik
AI787263
AU016967
Ctr1
Species Mus musculus
 Database cross references - Slc31a1
ExoCarta ExoCarta_20529
Vesiclepedia VP_20529
Entrez Gene 20529
UniProt Q8K211  
 Slc31a1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc31a1
Molecular Function
    copper ion transmembrane transporter activity GO:0005375 IDA
    copper ion transmembrane transporter activity GO:0005375 IMP
    copper ion transmembrane transporter activity GO:0005375 ISO
    copper ion transmembrane transporter activity GO:0005375 ISS
    copper ion binding GO:0005507 ISO
    copper ion binding GO:0005507 ISS
    protein binding GO:0005515 IPI
    silver ion transmembrane transporter activity GO:0015080 IDA
    silver ion transmembrane transporter activity GO:0015080 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    xenobiotic transmembrane transporter activity GO:0042910 IMP
Biological Process
    angiogenesis GO:0001525 IMP
    angiogenesis GO:0001525 ISO
    angiogenesis GO:0001525 ISS
    copper ion transport GO:0006825 IDA
    intracellular copper ion homeostasis GO:0006878 IGI
    copper ion import GO:0015677 IDA
    copper ion import GO:0015677 IMP
    copper ion import GO:0015677 IMP
    copper ion import GO:0015677 ISO
    plasma membrane copper ion transport GO:0015679 ISO
    plasma membrane copper ion transport GO:0015679 ISS
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISO
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISS
    xenobiotic transport GO:0042908 IMP
    xenobiotic transport GO:0042908 ISO
    xenobiotic transport GO:0042908 ISS
    protein complex oligomerization GO:0051259 ISO
    protein complex oligomerization GO:0051259 ISS
    establishment of localization in cell GO:0051649 IMP
    transmembrane transport GO:0055085 ISO
    cellular response to cisplatin GO:0072719 ISO
    copper ion import across plasma membrane GO:0098705 ISO
    silver ion transmembrane transport GO:1902601 IDA
    silver ion transmembrane transport GO:1902601 ISO
Subcellular Localization
    late endosome GO:0005770 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    intercalated disc GO:0014704 IDA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISO
    early endosome membrane GO:0031901 ISO
    early endosome membrane GO:0031901 ISS
    late endosome membrane GO:0031902 IEA
    neuronal cell body GO:0043025 ISO
    recycling endosome GO:0055037 IDA
    recycling endosome membrane GO:0055038 ISO
    recycling endosome membrane GO:0055038 ISS
 Experiment description of studies that identified Slc31a1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc31a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here