Gene description for Sox11
Gene name SRY (sex determining region Y)-box 11
Gene symbol Sox11
Other names/aliases 1110038H03Rik
6230403H02Rik
AI836553
end1
Species Mus musculus
 Database cross references - Sox11
ExoCarta ExoCarta_20666
Entrez Gene 20666
UniProt Q7M6Y2  
 Sox11 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sox11
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    DNA binding GO:0003677 IEA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 ISO
    enhancer sequence-specific DNA binding GO:0001158 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    translation factor activity, RNA binding GO:0008135 ISO
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 ISO
    transcription regulatory region sequence-specific DNA binding GO:0000976 ISO
    RNA polymerase II transcription coactivator activity GO:0001105 ISO
Biological Process
    lung morphogenesis GO:0060425 IMP
    limb bud formation GO:0060174 IMP
    negative regulation of gene expression GO:0010629 ISO
    closure of optic fissure GO:0061386 IMP
    transcription, DNA-templated GO:0006351 IEA
    hard palate development GO:0060022 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    positive regulation of neurogenesis GO:0050769 IDA
    positive regulation of hippo signaling GO:0035332 IMP
    multicellular organismal development GO:0007275 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of osteoblast differentiation GO:0045669 ISO
    outflow tract morphogenesis GO:0003151 IMP
    spinal cord development GO:0021510 IMP
    embryonic skeletal system morphogenesis GO:0048704 IMP
    positive regulation of BMP signaling pathway GO:0030513 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of ossification GO:0045778 ISO
    neural crest cell development GO:0014032 IMP
    ventricular septum morphogenesis GO:0060412 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    positive regulation of cell proliferation GO:0008284 IMP
    soft palate development GO:0060023 IMP
    positive regulation of lens epithelial cell proliferation GO:2001111 IMP
    positive regulation of gene expression GO:0010628 ISO
    noradrenergic neuron differentiation GO:0003357 ISO
    lens morphogenesis in camera-type eye GO:0002089 IMP
    nervous system development GO:0007399 IEA
    glial cell development GO:0021782 IMP
    positive regulation of hormone secretion GO:0046887 IMP
    eyelid development in camera-type eye GO:0061029 IMP
    negative regulation of lymphocyte proliferation GO:0050672 ISO
    sympathetic nervous system development GO:0048485 IMP
    somite development GO:0061053 IMP
    neural tube formation GO:0001841 IMP
    skeletal system development GO:0001501 IMP
    embryonic digestive tract morphogenesis GO:0048557 IMP
    transcription from RNA polymerase II promoter GO:0006366 IDA
    glial cell proliferation GO:0014009 IMP
    positive regulation of neuron differentiation GO:0045666 ISO
    positive regulation of stem cell proliferation GO:2000648 ISO
    neuroepithelial cell differentiation GO:0060563 IMP
    skeletal muscle cell differentiation GO:0035914 IMP
    negative regulation of transcription regulatory region DNA binding GO:2000678 ISO
    cell differentiation GO:0030154 IEA
    negative regulation of glial cell proliferation GO:0060253 ISO
    translation GO:0006412 ISO
    negative regulation of cell death GO:0060548 IMP
    cornea development in camera-type eye GO:0061303 IMP
    cardiac ventricle formation GO:0003211 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Sox11 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sox11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sox11 is involved
No pathways found





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