Gene description for Sox6
Gene name SRY (sex determining region Y)-box 6
Gene symbol Sox6
Other names/aliases AI987981
SOX-LZ
Species Mus musculus
 Database cross references - Sox6
ExoCarta ExoCarta_20679
Entrez Gene 20679
UniProt P40645  
 Sox6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sox6
Molecular Function
    sequence-specific DNA binding GO:0043565 IDA
    DNA binding GO:0003677 IDA
    protein heterodimerization activity GO:0046982 IPI
    transcription regulatory region DNA binding GO:0044212 IDA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IGI
Biological Process
    positive regulation of mesenchymal stem cell differentiation GO:2000741 ISO
    positive regulation of chondrocyte differentiation GO:0032332 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    cell fate commitment GO:0045165 IGI
    regulation of transcription, DNA-templated GO:0006355 IDA
    muscle cell differentiation GO:0042692 IDA
    regulation of gene expression GO:0010468 IMP
    cellular response to transforming growth factor beta stimulus GO:0071560 ISO
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    in utero embryonic development GO:0001701 IMP
    cell morphogenesis GO:0000902 IMP
    erythrocyte development GO:0048821 IMP
    hemopoiesis GO:0030097 IMP
    gene silencing GO:0016458 IMP
    oligodendrocyte differentiation GO:0048709 IMP
    multicellular organismal development GO:0007275 IEA
    erythrocyte differentiation GO:0030218 IMP
    cardiac muscle cell differentiation GO:0055007 IDA
    positive regulation of cartilage development GO:0061036 ISO
    cartilage development GO:0051216 IGI
    astrocyte differentiation GO:0048708 ISO
    post-embryonic development GO:0009791 IMP
    oligodendrocyte cell fate specification GO:0021778 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    transcription factor complex GO:0005667 IC
 Experiment description of studies that identified Sox6 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sox6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sox6 is involved
PathwayEvidenceSource
deactivation of the beta-catenin transactivating complex IEA Reactome





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