Gene description for Spin1
Gene name spindlin 1
Gene symbol Spin1
Other names/aliases Spin
Species Mus musculus
 Database cross references - Spin1
ExoCarta ExoCarta_20729
Vesiclepedia VP_20729
Entrez Gene 20729
UniProt Q61142  
 Spin1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Spin1
Molecular Function
    DNA binding GO:0003677 IEA
    methylated histone binding GO:0035064 IBA
    methylated histone binding GO:0035064 IDA
    methylated histone binding GO:0035064 ISO
    methylated histone binding GO:0035064 ISS
    histone reader activity GO:0140566 IDA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IBA
    female meiotic nuclear division GO:0007143 IC
    rRNA transcription GO:0009303 ISO
    rRNA transcription GO:0009303 ISS
    Wnt signaling pathway GO:0016055 IEA
    positive regulation of Wnt signaling pathway GO:0030177 ISO
    positive regulation of Wnt signaling pathway GO:0030177 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISS
    protein localization to chromatin GO:0071168 IDA
    transposable element silencing by piRNA-mediated DNA methylation GO:0141196 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    nucleolus GO:0005730 ISS
    spindle GO:0005819 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
 Experiment description of studies that identified Spin1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Spin1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pspc1  
Co-fractionation Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Mettl21e  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Spin1 is involved
No pathways found





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