Gene description for Spin1
Gene name spindlin 1
Gene symbol Spin1
Other names/aliases Spin
Species Mus musculus
 Database cross references - Spin1
ExoCarta ExoCarta_20729
Entrez Gene 20729
UniProt Q61142  
 Spin1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Spin1
Molecular Function
    DNA binding GO:0003677 IEA
    methylated histone binding GO:0035064 ISO
Biological Process
    rRNA transcription GO:0009303 ISO
    cell cycle GO:0007049 IEA
    multicellular organismal development GO:0007275 IEA
    gamete generation GO:0007276 IEA
    meiotic cell cycle GO:0051321 IEA
    Wnt signaling pathway GO:0016055 IEA
    female meiotic division GO:0007143 IC
    positive regulation of Wnt signaling pathway GO:0030177 ISO
    chromatin modification GO:0016568 IEA
Subcellular Localization
    nucleolus GO:0005730 ISO
    cytoskeleton GO:0005856 IEA
    spindle GO:0005819 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Spin1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Spin1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Spin1 is involved
No pathways found





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