Gene description for Spp1
Gene name secreted phosphoprotein 1
Gene symbol Spp1
Other names/aliases 2AR
Species Mus musculus
 Database cross references - Spp1
ExoCarta ExoCarta_20750
Entrez Gene 20750
UniProt P10923  
 Spp1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Spp1
Molecular Function
    extracellular matrix binding GO:0050840 IDA
    cytokine activity GO:0005125 NAS
Biological Process
    response to organic substance GO:0010033 ISO
    biomineral tissue development GO:0031214 IEA
    cellular response to fluid shear stress GO:0071498 IDA
    cell adhesion GO:0007155 ISO
    response to vitamin D GO:0033280 ISO
    positive regulation of cell-substrate adhesion GO:0010811 IDA
    ossification GO:0001503 IEA
    response to steroid hormone GO:0048545 ISO
    negative regulation of apoptotic process GO:0043066 NAS
    positive regulation of bone resorption GO:0045780 ISO
    osteoblast differentiation GO:0001649 ISO
    neutrophil chemotaxis GO:0030593 IGI
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    apical part of cell GO:0045177 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular region GO:0005576 NAS
    membrane-bounded vesicle GO:0031988 ISO
    cell projection GO:0042995 ISO
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Spp1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Spp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Spp1 is involved
Degradation of the extracellular matrix IEA Reactome
Integrin cell surface interactions IEA Reactome
Signaling by PDGF IEA Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here