Gene description for Sqle
Gene name squalene epoxidase
Gene symbol Sqle
Other names/aliases AI323792
Species Mus musculus
 Database cross references - Sqle
ExoCarta ExoCarta_20775
Entrez Gene 20775
UniProt P52019  
 Sqle identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Sqle
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    flavin adenine dinucleotide binding GO:0050660 IEA
    squalene monooxygenase activity GO:0004506 ISO
Biological Process
    response to organic substance GO:0010033 ISO
    metabolic process GO:0008152 IEA
    cholesterol metabolic process GO:0008203 ISO
    oxidation-reduction process GO:0055114 ISO
    cellular aromatic compound metabolic process GO:0006725 ISO
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IEA
    endoplasmic reticulum GO:0005783 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Sqle in exosomes
1
Experiment ID 263
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sqle
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sqle is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) IEA Reactome
Cholesterol biosynthesis IEA Reactome





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