Gene description for Scarb1
Gene name scavenger receptor class B, member 1
Gene symbol Scarb1
Other names/aliases AI120173
CD36
Cd36l1
Cla-1
Cla1
D5Ertd460e
Hdlq1
Hlb398
SR-B1
SR-BI
SRBI
Srb1
mSR-BI
Species Mus musculus
 Database cross references - Scarb1
ExoCarta ExoCarta_20778
Vesiclepedia VP_20778
Entrez Gene 20778
UniProt Q61009  
 Scarb1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Scarb1
Molecular Function
    lipopolysaccharide binding GO:0001530 IEA
    lipopolysaccharide binding GO:0001530 ISO
    amyloid-beta binding GO:0001540 IGI
    phosphatidylserine binding GO:0001786 ISO
    lipopolysaccharide immune receptor activity GO:0001875 IEA
    lipopolysaccharide immune receptor activity GO:0001875 ISO
    scavenger receptor activity GO:0005044 IBA
    high-density lipoprotein particle binding GO:0008035 IDA
    lipid binding GO:0008289 IBA
    low-density lipoprotein particle binding GO:0030169 IBA
    low-density lipoprotein particle binding GO:0030169 ISO
    low-density lipoprotein particle binding GO:0030169 ISS
    apolipoprotein binding GO:0034185 IPI
    apolipoprotein binding GO:0034185 ISO
    apolipoprotein A-I binding GO:0034186 IEA
    apolipoprotein A-I binding GO:0034186 ISO
    identical protein binding GO:0042802 ISO
    high-density lipoprotein particle receptor activity GO:0070506 ISO
    high-density lipoprotein particle receptor activity GO:0070506 ISS
Biological Process
    endothelial cell proliferation GO:0001935 IMP
    androgen biosynthetic process GO:0006702 ISO
    cholesterol catabolic process GO:0006707 IDA
    cholesterol catabolic process GO:0006707 IMP
    lipid transport GO:0006869 ISO
    phagocytosis, recognition GO:0006910 ISO
    positive regulation of triglyceride biosynthetic process GO:0010867 IMP
    positive regulation of cholesterol storage GO:0010886 ISO
    positive regulation of cholesterol storage GO:0010886 ISS
    regulation of phosphatidylcholine catabolic process GO:0010899 IMP
    phospholipid transport GO:0015914 IMP
    lipopolysaccharide transport GO:0015920 IEA
    lipopolysaccharide transport GO:0015920 ISO
    cholesterol transport GO:0030301 IDA
    cholesterol transport GO:0030301 IMP
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    detection of lipopolysaccharide GO:0032497 IEA
    detection of lipopolysaccharide GO:0032497 ISO
    cholesterol efflux GO:0033344 IBA
    cholesterol efflux GO:0033344 IDA
    cholesterol efflux GO:0033344 IMP
    cholesterol efflux GO:0033344 ISO
    high-density lipoprotein particle remodeling GO:0034375 IMP
    plasma lipoprotein particle clearance GO:0034381 IBA
    low-density lipoprotein particle clearance GO:0034383 IMP
    high-density lipoprotein particle clearance GO:0034384 ISO
    high-density lipoprotein particle clearance GO:0034384 ISS
    vitamin transmembrane transport GO:0035461 IEA
    vitamin transmembrane transport GO:0035461 ISO
    cholesterol homeostasis GO:0042632 IMP
    blood vessel endothelial cell migration GO:0043534 IMP
    recognition of apoptotic cell GO:0043654 IBA
    recognition of apoptotic cell GO:0043654 ISO
    recognition of apoptotic cell GO:0043654 ISS
    reverse cholesterol transport GO:0043691 IMP
    adhesion of symbiont to host GO:0044406 IEA
    adhesion of symbiont to host GO:0044406 ISO
    regulation of phagocytosis GO:0050764 ISO
    positive regulation of nitric-oxide synthase activity GO:0051000 ISO
    triglyceride homeostasis GO:0070328 IMP
    cholesterol import GO:0070508 IBA
    cholesterol import GO:0070508 IDA
    cholesterol import GO:0070508 IMP
    cholesterol import GO:0070508 ISO
    intestinal lipid absorption GO:0098856 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 IEA
    lysosome GO:0005764 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    caveola GO:0005901 IBA
    caveola GO:0005901 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    microvillus membrane GO:0031528 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Scarb1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Scarb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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