Gene description for Scarb1
Gene name scavenger receptor class B, member 1
Gene symbol Scarb1
Other names/aliases AI120173
Species Mus musculus
 Database cross references - Scarb1
ExoCarta ExoCarta_20778
Entrez Gene 20778
UniProt Q61009  
 Scarb1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Scarb1
Molecular Function
    phosphatidylserine binding GO:0001786 ISO
    protein homodimerization activity GO:0042803 ISO
    high-density lipoprotein particle receptor activity GO:0070506 ISS
    lipopolysaccharide binding GO:0001530 ISO
    low-density lipoprotein particle binding GO:0030169 ISS
    apolipoprotein A-I binding GO:0034186 ISO
    lipopolysaccharide receptor activity GO:0001875 ISO
    high-density lipoprotein particle binding GO:0008035 IDA
    apolipoprotein binding GO:0034185 ISO
Biological Process
    pattern recognition receptor signaling pathway GO:0002221 ISO
    endothelial cell proliferation GO:0001935 IMP
    recognition of apoptotic cell GO:0043654 ISS
    vitamin transmembrane transport GO:0035461 ISO
    lipopolysaccharide transport GO:0015920 ISO
    cholesterol catabolic process GO:0006707 IMP
    positive regulation of triglyceride biosynthetic process GO:0010867 IMP
    regulation of phosphatidylcholine catabolic process GO:0010899 IMP
    positive regulation of nitric-oxide synthase activity GO:0051000 ISO
    positive regulation of cholesterol storage GO:0010886 ISS
    receptor-mediated endocytosis GO:0006898 ISS
    cholesterol transport GO:0030301 IMP
    adhesion of symbiont to host GO:0044406 ISO
    high-density lipoprotein particle clearance GO:0034384 ISS
    androgen biosynthetic process GO:0006702 ISO
    phospholipid transport GO:0015914 IMP
    phagocytosis, recognition GO:0006910 ISO
    regulation of phagocytosis GO:0050764 ISO
    low-density lipoprotein particle clearance GO:0034383 IMP
    triglyceride homeostasis GO:0070328 IMP
    cholesterol import GO:0070508 ISO
    blood vessel endothelial cell migration GO:0043534 IMP
    detection of lipopolysaccharide GO:0032497 ISO
    high-density lipoprotein particle remodeling GO:0034375 IMP
    reverse cholesterol transport GO:0043691 IMP
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISO
    lipid transport GO:0006869 ISO
    cell adhesion GO:0007155 IEA
    cholesterol homeostasis GO:0042632 IMP
    cholesterol efflux GO:0033344 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    lysosomal membrane GO:0005765 ISO
    integral component of plasma membrane GO:0005887 IDA
    plasma membrane GO:0005886 ISS
    caveola GO:0005901 IDA
    membrane GO:0016020 IEA
    cell surface GO:0009986 ISO
    microvillus membrane GO:0031528 ISO
    integral component of membrane GO:0016021 IDA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Scarb1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Scarb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Scarb1 is involved
HDL-mediated lipid transport IEA Reactome
Scavenging by Class B Receptors IEA Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here