Gene description for Pycr1
Gene name pyrroline-5-carboxylate reductase 1
Gene symbol Pycr1
Other names/aliases -
Species Mus musculus
 Database cross references - Pycr1
ExoCarta ExoCarta_209027
Entrez Gene 209027
UniProt Q922W5  
 Pycr1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Pycr1
Molecular Function
    pyrroline-5-carboxylate reductase activity GO:0004735 ISO
    oxidoreductase activity GO:0016491 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    oxidation-reduction process GO:0055114 ISO
    proline biosynthetic process GO:0006561 ISO
    negative regulation of hydrogen peroxide-induced cell death GO:1903206 ISO
    cellular response to oxidative stress GO:0034599 ISO
    regulation of mitochondrial membrane potential GO:0051881 ISO
    cellular amino acid biosynthetic process GO:0008652 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Pycr1 in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pycr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pycr1 is involved
PathwayEvidenceSource
Amino acid synthesis and interconversion (transamination) IEA Reactome





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