Gene description for Papd7
Gene name PAP associated domain containing 7
Gene symbol Papd7
Other names/aliases LAK-1
POLK
Pols
TRF4
TRF4-1
Species Mus musculus
 Database cross references - Papd7
ExoCarta ExoCarta_210106
Vesiclepedia VP_210106
Entrez Gene 210106
UniProt Q6PB75  
 Papd7 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Papd7
Molecular Function
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    guanylyltransferase activity GO:0070568 ISO
    guanylyltransferase activity GO:0070568 ISS
    poly(A) RNA polymerase activity GO:1990817 IBA
    poly(A) RNA polymerase activity GO:1990817 IEA
Biological Process
    mRNA processing GO:0006397 IEA
    response to xenobiotic stimulus GO:0009410 ISO
    RNA 3'-end processing GO:0031123 IBA
    polyadenylation-dependent ncRNA catabolic process GO:0043634 IBA
    negative regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060212 ISO
    negative regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060212 ISS
    RNA 3' uridylation GO:0071076 ISO
    RNA 3' uridylation GO:0071076 ISS
    positive regulation of 3'-UTR-mediated mRNA stabilization GO:1905870 ISO
    positive regulation of 3'-UTR-mediated mRNA stabilization GO:1905870 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IBA
    cytoplasm GO:0005737 IEA
    Golgi apparatus GO:0005794 ISO
    TRAMP complex GO:0031499 IBA
    nuclear membrane GO:0031965 ISO
 Experiment description of studies that identified Papd7 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Papd7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Papd7 is involved
No pathways found





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