Gene description for Exoc3
Gene name exocyst complex component 3
Gene symbol Exoc3
Other names/aliases 2810050O03Rik
E430013E20Rik
Sec6
Sec6l1
Species Mus musculus
 Database cross references - Exoc3
ExoCarta ExoCarta_211446
Vesiclepedia VP_211446
Entrez Gene 211446
UniProt Q6KAR6  
 Exoc3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Exoc3
Molecular Function
    molecular_function GO:0003674 ND
    SNARE binding GO:0000149 IBA
Biological Process
    biological_process GO:0008150 ND
    exocyst localization GO:0051601 IBA
    exocytosis GO:0006887 IBA
    protein transport GO:0015031 IEA
    transport GO:0006810 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
    exocyst GO:0000145 IBA
 Experiment description of studies that identified Exoc3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Exoc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Exoc3 is involved
PathwayEvidenceSource
Insulin processing IEA Reactome
Translocation of GLUT4 to the plasma membrane IEA Reactome
VxPx cargo-targeting to cilium IEA Reactome





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