Gene description for Exoc3
Gene name exocyst complex component 3
Gene symbol Exoc3
Other names/aliases 2810050O03Rik
E430013E20Rik
Sec6
Sec6l1
Species Mus musculus
 Database cross references - Exoc3
ExoCarta ExoCarta_211446
Vesiclepedia VP_211446
Entrez Gene 211446
UniProt Q6KAR6  
 Exoc3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Exoc3
Molecular Function
    SNARE binding GO:0000149 IBA
Biological Process
    mitotic cytokinesis GO:0000281 NAS
    exocytosis GO:0006887 IBA
    vesicle docking involved in exocytosis GO:0006904 NAS
    protein transport GO:0015031 IEA
    exocyst localization GO:0051601 IBA
    membrane fission GO:0090148 NAS
    vesicle tethering involved in exocytosis GO:0090522 NAS
Subcellular Localization
    exocyst GO:0000145 IBA
    exocyst GO:0000145 NAS
    Golgi apparatus GO:0005794 IEA
    growth cone GO:0030426 IEA
    midbody GO:0030496 IEA
    secretory granule membrane GO:0030667 TAS
    presynaptic membrane GO:0042734 IEA
    presynaptic membrane GO:0042734 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified Exoc3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Exoc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zer1  
Co-fractionation Mus musculus
2 Capn5  
Co-fractionation Mus musculus
3 Selenbp2  
Co-fractionation Mus musculus
4 Map2k6  
Co-fractionation Mus musculus
5 Stap2  
Co-fractionation Mus musculus
6 Ncf4  
Co-fractionation Mus musculus
7 Slc25a23  
Co-fractionation Mus musculus
View the network image/svg+xml



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