Gene description for Slc39a14
Gene name solute carrier family 39 (zinc transporter), member 14
Gene symbol Slc39a14
Other names/aliases FAD-123
ZIP-14
Zip14
fad123
Species Mus musculus
 Database cross references - Slc39a14
ExoCarta ExoCarta_213053
Vesiclepedia VP_213053
Entrez Gene 213053
UniProt Q75N73  
 Slc39a14 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Slc39a14
Molecular Function
    iron ion transmembrane transporter activity GO:0005381 IDA
    manganese ion transmembrane transporter activity GO:0005384 IDA
    manganese ion transmembrane transporter activity GO:0005384 ISO
    manganese ion transmembrane transporter activity GO:0005384 ISS
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 ISO
    cadmium ion transmembrane transporter activity GO:0015086 IDA
    ferrous iron transmembrane transporter activity GO:0015093 IDA
    monoatomic anion:monoatomic cation symporter activity GO:0015296 IDA
    monoatomic cation:bicarbonate symporter activity GO:0140410 IBA
    monoatomic cation:bicarbonate symporter activity GO:0140410 IEA
    monoatomic cation:bicarbonate symporter activity GO:0140410 ISO
Biological Process
    chondrocyte differentiation GO:0002062 IMP
    gluconeogenesis GO:0006094 IMP
    iron ion transport GO:0006826 IDA
    zinc ion transport GO:0006829 IDA
    intracellular zinc ion homeostasis GO:0006882 IMP
    intracellular zinc ion homeostasis GO:0006882 ISO
    insulin receptor signaling pathway GO:0008286 IMP
    regulation of hormone levels GO:0010817 IMP
    bicarbonate transport GO:0015701 IEA
    intracellular monoatomic cation homeostasis GO:0030003 IBA
    cellular response to insulin stimulus GO:0032869 IMP
    iron import into cell GO:0033212 IMP
    iron import into cell GO:0033212 ISO
    iron ion transmembrane transport GO:0034755 IDA
    iron ion transmembrane transport GO:0034755 IMP
    iron ion transmembrane transport GO:0034755 ISO
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IMP
    manganese ion homeostasis GO:0055071 IMP
    cadmium ion transmembrane transport GO:0070574 IEA
    cellular response to glucose stimulus GO:0071333 IDA
    manganese ion transmembrane transport GO:0071421 IDA
    manganese ion transmembrane transport GO:0071421 ISO
    zinc ion transmembrane transport GO:0071577 IDA
    zinc ion transmembrane transport GO:0071577 ISO
    zinc ion import across plasma membrane GO:0071578 IBA
    zinc ion import across plasma membrane GO:0071578 ISO
    zinc ion import across plasma membrane GO:0071578 ISS
    monoatomic anion transmembrane transport GO:0098656 IEA
    inorganic cation transmembrane transport GO:0098662 IDA
    import across plasma membrane GO:0098739 ISO
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    early endosome membrane GO:0031901 ISO
    early endosome membrane GO:0031901 ISS
    late endosome membrane GO:0031902 ISO
    late endosome membrane GO:0031902 ISS
 Experiment description of studies that identified Slc39a14 in sEVs
1
Experiment ID 1101
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1102
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 1103
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for Slc39a14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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