Gene description for Zcchc6
Gene name zinc finger, CCHC domain containing 6
Gene symbol Zcchc6
Other names/aliases 6030448M23Rik
AA420405
Species Mus musculus
 Database cross references - Zcchc6
ExoCarta ExoCarta_214290
Vesiclepedia VP_214290
Entrez Gene 214290
UniProt Q5BLK4  
 Zcchc6 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zcchc6
Molecular Function
    zinc ion binding GO:0008270 IEA
    miRNA binding GO:0035198 ISO
    miRNA binding GO:0035198 ISS
    RNA uridylyltransferase activity GO:0050265 IBA
    RNA uridylyltransferase activity GO:0050265 ISO
    RNA uridylyltransferase activity GO:0050265 ISS
    RNA uridylyltransferase activity GO:0050265 TAS
    uridylyltransferase activity GO:0070569 IMP
    uridylyltransferase activity GO:0070569 ISO
    uridylyltransferase activity GO:0070569 ISS
Biological Process
    oocyte maturation GO:0001556 IMP
    miRNA metabolic process GO:0010586 ISO
    miRNA metabolic process GO:0010586 ISS
    pre-miRNA processing GO:0031054 ISO
    pre-miRNA processing GO:0031054 ISS
    RNA 3'-end processing GO:0031123 ISO
    RNA 3'-end processing GO:0031123 ISS
    histone mRNA catabolic process GO:0071044 ISS
    RNA 3' uridylation GO:0071076 IBA
    RNA 3' uridylation GO:0071076 IMP
    RNA 3' uridylation GO:0071076 ISO
    RNA 3' uridylation GO:0071076 ISS
    transposable element silencing by mRNA destabilization GO:0141008 ISO
    transposable element silencing by mRNA destabilization GO:0141008 ISS
    polyuridylation-dependent mRNA catabolic process GO:1990074 IMP
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
 Experiment description of studies that identified Zcchc6 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zcchc6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg16l1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Zcchc6 is involved
No pathways found





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