Gene description for Tcn2
Gene name transcobalamin 2
Gene symbol Tcn2
Other names/aliases AW208754
Tcn-2
Species Mus musculus
 Database cross references - Tcn2
ExoCarta ExoCarta_21452
Entrez Gene 21452
UniProt O88968  
 Tcn2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tcn2
Molecular Function
    cobalamin binding GO:0031419 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    cobalt ion transport GO:0006824 IEA
    transport GO:0006810 IEA
    ion transport GO:0006811 IEA
    cobalamin transport GO:0015889 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Tcn2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tcn2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tcn2 is involved
PathwayEvidenceSource
Cobalamin (Cbl, vitamin B12) transport and metabolism IEA Reactome





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