Gene description for Lrrtm3
Gene name leucine rich repeat transmembrane neuronal 3
Gene symbol Lrrtm3
Other names/aliases 9630044H04Rik
Species Mus musculus
 Database cross references - Lrrtm3
ExoCarta ExoCarta_216028
Vesiclepedia VP_216028
Entrez Gene 216028
UniProt Q8BZ81  
 Lrrtm3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lrrtm3
Biological Process
    positive regulation of synapse assembly GO:0051965 IDA
    positive regulation of amyloid-beta formation GO:1902004 IMP
    positive regulation of amyloid-beta formation GO:1902004 ISO
    regulation of presynapse assembly GO:1905606 IEA
    regulation of presynapse assembly GO:1905606 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    membrane GO:0016020 ISS
    extracellular matrix GO:0031012 IBA
    postsynaptic density membrane GO:0098839 IDA
    postsynaptic density membrane GO:0098839 IEP
    postsynaptic density membrane GO:0098839 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Lrrtm3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lrrtm3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Lrrtm3 is involved
PathwayEvidenceSource
Neurexins and neuroligins IEA Reactome
Neuronal System IEA Reactome
Protein-protein interactions at synapses IEA Reactome





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