Gene description for Efemp1
Gene name epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Gene symbol Efemp1
Other names/aliases -
Species Mus musculus
 Database cross references - Efemp1
ExoCarta ExoCarta_216616
Vesiclepedia VP_216616
Entrez Gene 216616
UniProt Q8BPB5  
 Efemp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Efemp1
Molecular Function
    epidermal growth factor receptor activity GO:0005006 ISO
    epidermal growth factor receptor activity GO:0005006 ISS
    epidermal growth factor receptor binding GO:0005154 ISO
    epidermal growth factor receptor binding GO:0005154 ISS
    extracellular matrix structural constituent GO:0005201 RCA
    calcium ion binding GO:0005509 IEA
    growth factor activity GO:0008083 IEA
Biological Process
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of DNA-templated transcription GO:0006355 ISS
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    epidermal growth factor receptor signaling pathway GO:0007173 ISS
    positive regulation of cell population proliferation GO:0008284 ISO
    negative regulation of neuron projection development GO:0010977 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 ISS
    positive regulation of cell projection organization GO:0031346 ISO
    negative regulation of chondrocyte differentiation GO:0032331 ISO
    negative regulation of chondrocyte differentiation GO:0032331 ISS
    camera-type eye development GO:0043010 IEA
    embryonic eye morphogenesis GO:0048048 IEA
    post-embryonic eye morphogenesis GO:0048050 IEA
    regulation of glial cell migration GO:1903975 ISO
Subcellular Localization
    basement membrane GO:0005604 ISO
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    extracellular matrix GO:0031012 ISS
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified Efemp1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Efemp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Efemp1 is involved
No pathways found





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