Gene description for Gemin5
Gene name gem (nuclear organelle) associated protein 5
Gene symbol Gemin5
Other names/aliases AA407055
AA407208
AI451603
BB194447
C330013N08
Species Mus musculus
 Database cross references - Gemin5
ExoCarta ExoCarta_216766
Entrez Gene 216766
UniProt Q8BX17  
 Gemin5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Gemin5
Molecular Function
    snRNA binding GO:0017069 ISO
    poly(A) RNA binding GO:0044822 ISO
    RNA binding GO:0003723 IEA
Biological Process
    RNA splicing GO:0008380 IEA
    mRNA processing GO:0006397 IEA
    spliceosomal snRNP assembly GO:0000387 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    SMN-Sm protein complex GO:0034719 ISO
    cytosol GO:0005829 ISO
    membrane GO:0016020 ISO
    nucleus GO:0005634 ISO
    nuclear body GO:0016604 ISO
    SMN complex GO:0032797 ISO
 Experiment description of studies that identified Gemin5 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Gemin5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gemin5 is involved
PathwayEvidenceSource
snRNP Assembly IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here