Gene description for Nlgn2
Gene name neuroligin 2
Gene symbol Nlgn2
Other names/aliases NL2
Species Mus musculus
 Database cross references - Nlgn2
ExoCarta ExoCarta_216856
Entrez Gene 216856
UniProt Q69ZK9  
 Nlgn2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nlgn2
Molecular Function
    receptor activity GO:0004872 IBA
    cell adhesion molecule binding GO:0050839 IPI
    neurexin family protein binding GO:0042043 IPI
    carboxylic ester hydrolase activity GO:0052689 IBA
    protein binding GO:0005515 IPI
Biological Process
    synapse organization GO:0050808 ISO
    positive regulation of synaptic transmission, GABAergic GO:0032230 IMP
    neuromuscular process controlling balance GO:0050885 IMP
    social behavior GO:0035176 ISO
    regulation of synaptic transmission GO:0050804 IGI
    positive regulation of synapse assembly GO:0051965 ISO
    positive regulation of dendritic spine development GO:0060999 ISO
    terminal button organization GO:0072553 ISO
    positive regulation of inhibitory postsynaptic membrane potential GO:0097151 ISO
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 IMP
    presynaptic membrane assembly GO:0097105 ISO
    regulation of respiratory gaseous exchange by neurological system process GO:0002087 IGI
    positive regulation of protein localization to synapse GO:1902474 ISO
    thigmotaxis GO:0001966 ISO
    regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:2000311 IMP
    postsynaptic density protein 95 clustering GO:0097119 IDA
    locomotory exploration behavior GO:0035641 IMP
    protein localization to synapse GO:0035418 IDA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IMP
    positive regulation of cell proliferation GO:0008284 ISO
    jump response GO:0007630 ISO
    gephyrin clustering involved in postsynaptic density assembly GO:0097116 IDA
    neuron cell-cell adhesion GO:0007158 ISO
    positive regulation of insulin secretion GO:0032024 ISO
    positive regulation of t-SNARE clustering GO:1904034 ISO
    synapse assembly GO:0007416 ISO
    cell adhesion GO:0007155 IEA
    sensory perception of pain GO:0019233 IMP
    positive regulation of synaptic vesicle clustering GO:2000809 IDA
    postsynaptic membrane assembly GO:0097104 IDA
    insulin metabolic process GO:1901142 ISO
Subcellular Localization
    synapse GO:0045202 IDA
    inhibitory synapse GO:0060077 ISO
    excitatory synapse GO:0060076 ISO
    membrane GO:0016020 IEA
    integral component of plasma membrane GO:0005887 ISO
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 ISO
    plasma membrane GO:0005886 ISO
    ribbon synapse GO:0097470 ISO
    postsynaptic membrane GO:0045211 ISO
    dendritic shaft GO:0043198 ISO
    cell junction GO:0030054 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Nlgn2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nlgn2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nlgn2 is involved
No pathways found





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