Gene description for Atxn7l3
Gene name ataxin 7-like 3
Gene symbol Atxn7l3
Other names/aliases E030022H21Rik
Species Mus musculus
 Database cross references - Atxn7l3
ExoCarta ExoCarta_217218
Vesiclepedia VP_217218
Entrez Gene 217218
UniProt A2AWT3  
 Atxn7l3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Atxn7l3
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 ISO
    transcription coactivator activity GO:0003713 ISS
    zinc ion binding GO:0008270 IEA
    nuclear receptor coactivator activity GO:0030374 IEA
    nuclear receptor coactivator activity GO:0030374 ISO
Biological Process
    regulation of DNA repair GO:0006282 NAS
    chromatin organization GO:0006325 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 IBA
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of DNA-templated transcription GO:0045893 NAS
Subcellular Localization
    SAGA complex GO:0000124 IBA
    SAGA complex GO:0000124 ISO
    SAGA complex GO:0000124 ISS
    SAGA complex GO:0000124 NAS
    nucleus GO:0005634 ISO
    transcription factor TFTC complex GO:0033276 NAS
    DUBm complex GO:0071819 IBA
    DUBm complex GO:0071819 IEA
    DUBm complex GO:0071819 ISO
 Experiment description of studies that identified Atxn7l3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Atxn7l3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg12  
Negative Genetic Mus musculus
View the network image/svg+xml
 Pathways in which Atxn7l3 is involved
No pathways found





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