Gene description for Atxn7l3
Gene name ataxin 7-like 3
Gene symbol Atxn7l3
Other names/aliases E030022H21Rik
Species Mus musculus
 Database cross references - Atxn7l3
ExoCarta ExoCarta_217218
Entrez Gene 217218
UniProt A2AWT3  
 Atxn7l3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Atxn7l3
Molecular Function
    metal ion binding GO:0046872 IEA
    transcription coactivator activity GO:0003713 ISO
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 ISO
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    chromatin modification GO:0016568 IEA
    histone deubiquitination GO:0016578 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    SAGA complex GO:0000124 ISO
 Experiment description of studies that identified Atxn7l3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Atxn7l3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atxn7l3 is involved
PathwayEvidenceSource
HATs acetylate histones IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here