Gene description for Tgtp1
Gene name T cell specific GTPase 1
Gene symbol Tgtp1
Other names/aliases Gtp2
Irgb6
Mg21
Tgtp
Species Mus musculus
 Database cross references - Tgtp1
ExoCarta ExoCarta_21822
Vesiclepedia VP_21822
Entrez Gene 21822
 Tgtp1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tgtp1
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IDA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 ISS
    membrane scission GTPase motor activity GO:1990606 IEA
Biological Process
    autophagosome assembly GO:0000045 IBA
    immune response GO:0006955 NAS
    response to virus GO:0009615 IDA
    response to bacterium GO:0009617 IEP
    response to type II interferon GO:0034341 IDA
    response to interferon-alpha GO:0035455 IDA
    cellular response to interferon-beta GO:0035458 IBA
    cellular response to interferon-beta GO:0035458 IDA
    defense response to protozoan GO:0042832 IDA
    innate immune response GO:0045087 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum membrane GO:0005789 IBA
    Golgi apparatus GO:0005794 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Tgtp1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tgtp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Igtp  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Tgtp1 is involved
No pathways found





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