Gene description for Atp6v0a2
Gene name ATPase, H+ transporting, lysosomal V0 subunit A2
Gene symbol Atp6v0a2
Other names/aliases 8430408C20Rik
AI385560
ATP6a2
AW489264
Atp6n1d
Atp6n2
C76904
ISF
J6B7
SHIF
Stv1
TJ6M
TJ6s
Tj6
V-ATPase 116 kDa
V-ATPase a2
Species Mus musculus
 Database cross references - Atp6v0a2
ExoCarta ExoCarta_21871
Vesiclepedia VP_21871
Entrez Gene 21871
UniProt P15920  
 Atp6v0a2 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Atp6v0a2
Molecular Function
    protein binding GO:0005515 IPI
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IEA
    ATPase binding GO:0051117 IBA
Biological Process
    intracellular iron ion homeostasis GO:0006879 ISO
    intracellular iron ion homeostasis GO:0006879 ISS
    vacuolar acidification GO:0007035 IBA
    cellular response to increased oxygen levels GO:0036295 ISO
    cellular response to increased oxygen levels GO:0036295 ISS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    vacuolar proton-transporting V-type ATPase, V0 domain GO:0000220 IEA
    acrosomal vesicle GO:0001669 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    focal adhesion GO:0005925 IEA
    focal adhesion GO:0005925 ISO
    endosome membrane GO:0010008 IEA
    vacuolar proton-transporting V-type ATPase complex GO:0016471 IBA
    proton-transporting V-type ATPase complex GO:0033176 IDA
    proton-transporting V-type ATPase, V0 domain GO:0033179 IDA
    intracellular organelle GO:0043229 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Atp6v0a2 in sEVs
1
Experiment ID 1101
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1102
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 1103
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for Atp6v0a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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