Gene description for Tnfaip1
Gene name tumor necrosis factor, alpha-induced protein 1 (endothelial)
Gene symbol Tnfaip1
Other names/aliases Edp-1
Species Mus musculus
 Database cross references - Tnfaip1
ExoCarta ExoCarta_21927
Entrez Gene 21927
UniProt O70479  
 Tnfaip1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Tnfaip1
Molecular Function
    GTP-Rho binding GO:0017049 ISO
    ubiquitin-protein transferase activity GO:0004842 ISO
    protein domain specific binding GO:0019904 ISO
Biological Process
    DNA replication GO:0006260 ISO
    protein ubiquitination GO:0016567 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    stress fiber assembly GO:0043149 ISO
    protein homooligomerization GO:0051260 IEA
    positive regulation of DNA replication GO:0045740 ISO
    cell migration GO:0016477 ISO
    negative regulation of Rho protein signal transduction GO:0035024 ISO
Subcellular Localization
    endosome GO:0005768 ISO
    nucleus GO:0005634 IEA
    nucleolus GO:0005730 ISO
    Cul3-RING ubiquitin ligase complex GO:0031463 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Tnfaip1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tnfaip1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tnfaip1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here