Gene description for Tnfsf8
Gene name tumor necrosis factor (ligand) superfamily, member 8
Gene symbol Tnfsf8
Other names/aliases CD153
CD30LG
Cd30l
Species Mus musculus
 Database cross references - Tnfsf8
ExoCarta ExoCarta_21949
Entrez Gene 21949
UniProt P32972  
 Tnfsf8 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tnfsf8
Molecular Function
    cytokine activity GO:0005125 IEA
    tumor necrosis factor receptor binding GO:0005164 IEA
Biological Process
    immune response GO:0006955 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    defense response to Gram-positive bacterium GO:0050830 IMP
    CD8-positive, alpha-beta T cell differentiation GO:0043374 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified Tnfsf8 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tnfsf8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tnfsf8 is involved
No pathways found





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