Gene description for Tph1
Gene name tryptophan hydroxylase 1
Gene symbol Tph1
Other names/aliases Tph
Species Mus musculus
 Database cross references - Tph1
ExoCarta ExoCarta_21990
Vesiclepedia VP_21990
Entrez Gene 21990
UniProt P17532  
 Tph1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tph1
Molecular Function
    tryptophan 5-monooxygenase activity GO:0004510 IBA
    tryptophan 5-monooxygenase activity GO:0004510 IDA
    tryptophan 5-monooxygenase activity GO:0004510 ISO
    iron ion binding GO:0005506 IEA
Biological Process
    platelet degranulation GO:0002576 IMP
    circadian rhythm GO:0007623 IEA
    aromatic amino acid metabolic process GO:0009072 IEA
    negative regulation of ossification GO:0030279 IEA
    negative regulation of ossification GO:0030279 ISO
    response to immobilization stress GO:0035902 IEA
    serotonin biosynthetic process GO:0042427 IEA
    serotonin biosynthetic process GO:0042427 IMP
    positive regulation of fat cell differentiation GO:0045600 IMP
    bone remodeling GO:0046849 IGI
    mammary gland alveolus development GO:0060749 IMP
    regulation of hemostasis GO:1900046 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified Tph1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tph1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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