Gene description for Tpp2
Gene name tripeptidyl peptidase II
Gene symbol Tpp2
Other names/aliases TPP-2
TppII
Species Mus musculus
 Database cross references - Tpp2
ExoCarta ExoCarta_22019
Entrez Gene 22019
UniProt Q64514  
 Tpp2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Tpp2
Molecular Function
    peptide binding GO:0042277 ISO
    serine-type peptidase activity GO:0008236 IEA
    serine-type endopeptidase activity GO:0004252 IBA
    peptidase activity GO:0008233 IEA
    aminopeptidase activity GO:0004177 IEA
    tripeptidyl-peptidase activity GO:0008240 ISO
    hydrolase activity GO:0016787 IEA
Biological Process
    proteolysis GO:0006508 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Tpp2 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tpp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tpp2 is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome





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