Gene description for Tpp2
Gene name tripeptidyl peptidase II
Gene symbol Tpp2
Other names/aliases TPP-2
Species Mus musculus
 Database cross references - Tpp2
ExoCarta ExoCarta_22019
Entrez Gene 22019
UniProt Q64514  
 Tpp2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Tpp2
Molecular Function
    peptide binding GO:0042277 ISO
    serine-type peptidase activity GO:0008236 IEA
    serine-type endopeptidase activity GO:0004252 IBA
    peptidase activity GO:0008233 IEA
    aminopeptidase activity GO:0004177 IEA
    tripeptidyl-peptidase activity GO:0008240 ISO
    hydrolase activity GO:0016787 IEA
Biological Process
    proteolysis GO:0006508 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Tpp2 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tpp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tpp2 is involved
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome

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