Gene description for Traf4
Gene name TNF receptor associated factor 4
Gene symbol Traf4
Other names/aliases A530032M13Rik
CART1
msp2
Species Mus musculus
 Database cross references - Traf4
ExoCarta ExoCarta_22032
Entrez Gene 22032
UniProt Q61382  
 Traf4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Traf4
Molecular Function
    WW domain binding GO:0050699 ISO
    protein kinase binding GO:0019901 IPI
    zinc ion binding GO:0008270 IEA
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    thioesterase binding GO:0031996 ISO
    tumor necrosis factor receptor binding GO:0005164 ISO
    ubiquitin-protein transferase activity GO:0004842 IEA
Biological Process
    signal transduction GO:0007165 IEA
    protein ubiquitination GO:0016567 IEA
    positive regulation of protein kinase activity GO:0045860 ISO
    positive regulation of JNK cascade GO:0046330 ISO
    multicellular organismal development GO:0007275 IEA
    activation of NF-kappaB-inducing kinase activity GO:0007250 IEA
    apoptotic process GO:0006915 IEA
    respiratory gaseous exchange GO:0007585 IMP
    respiratory tube development GO:0030323 IMP
    regulation of apoptotic process GO:0042981 IEA
    positive regulation of protein homodimerization activity GO:0090073 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    plasma membrane GO:0005886 IEA
    cell junction GO:0030054 IEA
    bicellular tight junction GO:0005923 IEA
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Traf4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Traf4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Traf4 is involved
No pathways found





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