Gene description for FCER2
Gene name Fc fragment of IgE, low affinity II, receptor for (CD23)
Gene symbol FCER2
Other names/aliases BLAST-2
CD23
CD23A
CLEC4J
FCE2
IGEBF
Species Homo sapiens
 Database cross references - FCER2
ExoCarta ExoCarta_2208
Entrez Gene 2208
HGNC 3612
MIM 151445
UniProt P06734  
 FCER2 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for FCER2
Molecular Function
    carbohydrate binding GO:0030246 IEA
    integrin binding GO:0005178 TAS
    metal ion binding GO:0046872 IEA
    IgE binding GO:0019863 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IDA
    Notch signaling pathway GO:0007219 TAS
    positive regulation of killing of cells of other organism GO:0051712 IDA
    positive regulation of nitric-oxide synthase activity GO:0051000 IDA
    positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified FCER2 in exosomes
1
Experiment ID 79
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for FCER2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CR2 1380
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 FYN 2534
Affinity Capture-MS Homo sapiens
3 ITGAX 3687
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FCER2 is involved
PathwayEvidenceSource
NOTCH2 intracellular domain regulates transcription TAS Reactome





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