Gene description for Dpysl3
Gene name dihydropyrimidinase-like 3
Gene symbol Dpysl3
Other names/aliases CRMP-4
DRP-3
TUC4
ULIP-1
Ulip
Ulip1
Species Mus musculus
 Database cross references - Dpysl3
ExoCarta ExoCarta_22240
Entrez Gene 22240
UniProt Q62188  
 Dpysl3 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Dpysl3
Molecular Function
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 IEA
    chondroitin sulfate binding GO:0035374 ISO
    phosphoprotein binding GO:0051219 IPI
    SH3 domain binding GO:0017124 ISO
    hydrolase activity GO:0016787 IEA
    protein binding GO:0005515 IPI
Biological Process
    nervous system development GO:0007399 IDA
    negative regulation of neuron projection development GO:0010977 ISO
    actin crosslink formation GO:0051764 ISO
    actin filament bundle assembly GO:0051017 ISO
    negative regulation of cell migration GO:0030336 ISO
    positive regulation of neuron projection development GO:0010976 ISO
    positive regulation of filopodium assembly GO:0051491 ISO
    protein homooligomerization GO:0051260 ISO
Subcellular Localization
    exocytic vesicle GO:0070382 ISO
    filamentous actin GO:0031941 ISO
    growth cone GO:0030426 ISO
    cytosol GO:0005829 ISO
    cell body GO:0044297 ISO
    cytoplasm GO:0005737 IEA
    cell projection GO:0042995 IEA
    lamellipodium GO:0030027 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Dpysl3 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Dpysl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dpysl3 is involved
PathwayEvidenceSource
CRMPs in Sema3A signaling IEA Reactome





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