Gene description for Trpv2
Gene name transient receptor potential cation channel, subfamily V, member 2
Gene symbol Trpv2
Other names/aliases GRC
OTRPC2
VRL-1
Vrl1
Species Mus musculus
 Database cross references - Trpv2
ExoCarta ExoCarta_22368
Entrez Gene 22368
UniProt Q9WTR1  
 Trpv2 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Trpv2
Molecular Function
    ion channel activity GO:0005216 IEA
    cation channel activity GO:0005261 ISO
    calcium channel activity GO:0005262 IDA
Biological Process
    cation transmembrane transport GO:0098655 ISO
    positive regulation of calcium ion import GO:0090280 IMP
    response to heat GO:0009408 ISO
    ion transport GO:0006811 IEA
    calcium ion transport GO:0006816 IEA
    response to temperature stimulus GO:0009266 ISO
    apoptotic process GO:0006915 IDA
    calcium ion transmembrane transport GO:0070588 IDA
    transmembrane transport GO:0055085 IEA
    negative regulation of cell proliferation GO:0008285 ISO
    positive regulation of axon extension GO:0045773 IMP
    transport GO:0006810 IEA
Subcellular Localization
    growth cone membrane GO:0032584 IDA
    cell surface GO:0009986 IDA
    cell body GO:0044297 IDA
    cytoplasm GO:0005737 ISO
    endomembrane system GO:0012505 ISO
    intracellular GO:0005622 IDA
    integral component of membrane GO:0016021 IEA
    axonal growth cone GO:0044295 IDA
    lamellipodium GO:0030027 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IEA
    axon GO:0030424 IDA
 Experiment description of studies that identified Trpv2 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Trpv2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trpv2 is involved
PathwayEvidenceSource
TRP channels IEA Reactome





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