Gene description for Vtn
Gene name vitronectin
Gene symbol Vtn
Other names/aliases AI256434
Vn
Species Mus musculus
 Database cross references - Vtn
ExoCarta ExoCarta_22370
Entrez Gene 22370
UniProt P29788  
 Vtn identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Vtn
Molecular Function
    polysaccharide binding GO:0030247 IEA
    heparin binding GO:0008201 IEA
    integrin binding GO:0005178 ISO
    collagen binding GO:0005518 ISO
    scavenger receptor activity GO:0005044 IEA
    extracellular matrix binding GO:0050840 IDA
    identical protein binding GO:0042802 ISO
Biological Process
    cell adhesion mediated by integrin GO:0033627 ISO
    cell-matrix adhesion GO:0007160 ISO
    positive regulation of protein binding GO:0032092 ISO
    smooth muscle cell-matrix adhesion GO:0061302 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    negative regulation of endopeptidase activity GO:0010951 ISO
    endodermal cell differentiation GO:0035987 ISO
    protein polymerization GO:0051258 ISO
    extracellular matrix organization GO:0030198 IDA
    positive regulation of cell-substrate adhesion GO:0010811 IDA
    liver regeneration GO:0097421 ISO
    cell adhesion GO:0007155 IEA
    immune response GO:0006955 IEA
Subcellular Localization
    rough endoplasmic reticulum lumen GO:0048237 ISO
    basement membrane GO:0005604 ISO
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 ISO
    cytoplasm GO:0005737 ISO
    proteinaceous extracellular matrix GO:0005578 IDA
    Golgi lumen GO:0005796 ISO
    blood microparticle GO:0072562 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Vtn in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Vtn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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