Gene description for Bag6
Gene name BCL2-associated athanogene 6
Gene symbol Bag6
Other names/aliases 2410045D21Rik
AA408914
BAG-6
Bat3
D17H6S52E
G3
Scythe
Species Mus musculus
 Database cross references - Bag6
ExoCarta ExoCarta_224727
Vesiclepedia VP_224727
Entrez Gene 224727
UniProt Q9Z1R2  
 Bag6 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Bag6
Molecular Function
    ubiquitin protein ligase binding GO:0031625 ISO
    ribosome binding GO:0043022 ISO
    protein binding GO:0005515 IPI
    polyubiquitin binding GO:0031593 IDA
    Hsp70 protein binding GO:0030544 IPI
    proteasome binding GO:0070628 IDA
Biological Process
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IMP
    embryo development GO:0009790 IMP
    negative regulation of proteolysis GO:0045861 IMP
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 ISO
    synaptonemal complex assembly GO:0007130 IMP
    brain development GO:0007420 IMP
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 IMP
    negative regulation of apoptotic process GO:0043066 IGI
    regulation of apoptotic process GO:0042981 RCA
    transport GO:0006810 IEA
    internal peptidyl-lysine acetylation GO:0018393 ISO
    chromatin modification GO:0016568 IEA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISO
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    kidney development GO:0001822 IMP
    spermatogenesis GO:0007283 IMP
    immune system process GO:0002376 IEA
    cell differentiation GO:0030154 IEA
    protein stabilization GO:0050821 IMP
    apoptotic process GO:0006915 RCA
    lung development GO:0030324 IMP
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 ISO
    intracellular GO:0005622 IMP
    BAT3 complex GO:0071818 ISO
    cytosol GO:0005829 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Bag6 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Bag6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bag6 is involved
No pathways found





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