Gene description for Ubr2
Gene name ubiquitin protein ligase E3 component n-recognin 2
Gene symbol Ubr2
Other names/aliases 9930021A08Rik
AI462103
AW540746
E130209G04Rik
mKIAA0349
Species Mus musculus
 Database cross references - Ubr2
ExoCarta ExoCarta_224826
Vesiclepedia VP_224826
Entrez Gene 224826
UniProt Q6WKZ8  
 Ubr2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ubr2
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin protein ligase activity GO:0061630 IGI
    ubiquitin protein ligase activity GO:0061630 ISO
    L-leucine binding GO:0070728 IEA
    L-leucine binding GO:0070728 ISO
    histone H2A ubiquitin ligase activity GO:0141053 IDA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    reciprocal meiotic recombination GO:0007131 IMP
    male meiotic nuclear division GO:0007140 IMP
    male meiosis I GO:0007141 IMP
    spermatogenesis GO:0007283 IMP
    spermatogenesis GO:0007283 IMP
    transposable element silencing GO:0010526 IMP
    protein ubiquitination GO:0016567 IBA
    heterochromatin formation GO:0031507 IDA
    negative regulation of TOR signaling GO:0032007 ISO
    negative regulation of TOR signaling GO:0032007 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of T cell receptor signaling pathway GO:0050862 IEA
    positive regulation of T cell receptor signaling pathway GO:0050862 ISO
    protein K63-linked ubiquitination GO:0070534 IEA
    protein K63-linked ubiquitination GO:0070534 ISO
    cellular response to L-leucine GO:0071233 ISO
    cellular response to L-leucine GO:0071233 ISS
    ubiquitin-dependent protein catabolic process via the N-end rule pathway GO:0071596 IBA
    ubiquitin-dependent protein catabolic process via the N-end rule pathway GO:0071596 IDA
    ubiquitin-dependent protein catabolic process via the N-end rule pathway GO:0071596 ISO
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    ubiquitin ligase complex GO:0000151 IGI
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Ubr2 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ubr2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tex19.1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Plin2  
Affinity Capture-Western Mus musculus
3 Use1  
Affinity Capture-Western Mus musculus
4 ATXN3 4287
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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