Gene description for Ubr2
Gene name ubiquitin protein ligase E3 component n-recognin 2
Gene symbol Ubr2
Other names/aliases 9930021A08Rik
Species Mus musculus
 Database cross references - Ubr2
ExoCarta ExoCarta_224826
Entrez Gene 224826
UniProt Q6WKZ8  
 Ubr2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ubr2
Molecular Function
    ligase activity GO:0016874 IEA
    protein binding GO:0005515 IPI
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    metal ion binding GO:0046872 IEA
    leucine binding GO:0070728 ISO
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    protein-glycine ligase activity, elongating GO:0070737 IEA
    protein-glutamic acid ligase activity GO:0070739 IEA
    ubiquitin protein ligase activity GO:0061630 IGI
    protein-glycine ligase activity, initiating GO:0070736 IEA
    protein-glycine ligase activity GO:0070735 IEA
    zinc ion binding GO:0008270 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
Biological Process
    spermatogenesis GO:0007283 IMP
    chromatin silencing GO:0006342 IDA
    histone H2A ubiquitination GO:0033522 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    cellular response to leucine GO:0071233 ISO
    negative regulation of TOR signaling GO:0032007 ISO
    protein ubiquitination GO:0016567 IGI
    protein catabolic process GO:0030163 IEA
    male meiosis I GO:0007141 IMP
    ubiquitin-dependent protein catabolic process via the N-end rule pathway GO:0071596 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    plasma membrane GO:0005886 ISO
    ubiquitin ligase complex GO:0000151 IGI
    nucleoplasm GO:0005654 ISO
    chromatin GO:0000785 IDA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Ubr2 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Ubr2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ubr2 is involved
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome

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