Gene description for Dsg1b
Gene name desmoglein 1 beta
Gene symbol Dsg1b
Other names/aliases Dsg5
Species Mus musculus
 Database cross references - Dsg1b
ExoCarta ExoCarta_225256
Vesiclepedia VP_225256
Entrez Gene 225256
UniProt Q7TSF1  
 Dsg1b identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dsg1b
Molecular Function
    calcium ion binding GO:0005509 IEA
    gamma-catenin binding GO:0045295 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    cell adhesion GO:0007155 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
Subcellular Localization
    apical plasma membrane GO:0016324 ISO
    plasma membrane GO:0005886 IEA
    cell-cell junction GO:0005911 ISO
    lateral plasma membrane GO:0016328 ISO
    desmosome GO:0030057 IDA
    integral component of membrane GO:0016021 IEA
    cell junction GO:0030054 IEA
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    cytoplasmic side of plasma membrane GO:0009898 ISO
 Experiment description of studies that identified Dsg1b in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dsg1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dsg1b is involved
PathwayEvidenceSource
Apoptotic cleavage of cell adhesion proteins IEA Reactome





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