Gene description for Ppp2r5a
Gene name protein phosphatase 2, regulatory subunit B', alpha
Gene symbol Ppp2r5a
Other names/aliases PR61alpha
Species Mus musculus
 Database cross references - Ppp2r5a
ExoCarta ExoCarta_226849
Entrez Gene 226849
UniProt Q6PD03  
 Ppp2r5a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ppp2r5a
Molecular Function
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 ISO
    protein phosphatase type 2A regulator activity GO:0008601 IEA
Biological Process
    signal transduction GO:0007165 IEA
    negative regulation of lipid kinase activity GO:0090219 ISO
    negative regulation of establishment of protein localization to plasma membrane GO:0090005 ISO
    positive regulation of protein dephosphorylation GO:0035307 ISO
Subcellular Localization
    Z disc GO:0030018 IDA
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    chromosome GO:0005694 IEA
    nucleus GO:0005634 IEA
    M band GO:0031430 IDA
    chromosome, centromeric region GO:0000775 IEA
    protein phosphatase type 2A complex GO:0000159 ISO
 Experiment description of studies that identified Ppp2r5a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ppp2r5a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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