Gene description for Zhx1
Gene name zinc fingers and homeoboxes 1
Gene symbol Zhx1
Other names/aliases -
Species Mus musculus
 Database cross references - Zhx1
ExoCarta ExoCarta_22770
Vesiclepedia VP_22770
Entrez Gene 22770
UniProt P70121  
 Zhx1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zhx1
Molecular Function
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA binding GO:0003677 IEA
    DNA binding GO:0003677 ISO
    DNA-binding transcription factor activity GO:0003700 IEA
    DNA-binding transcription factor activity GO:0003700 ISO
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein heterodimerization activity GO:0046982 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Zhx1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zhx1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Utp3  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Zhx1 is involved
No pathways found





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