Gene description for Slc30a4
Gene name solute carrier family 30 (zinc transporter), member 4
Gene symbol Slc30a4
Other names/aliases Znt4
lm
znT-4
Species Mus musculus
 Database cross references - Slc30a4
ExoCarta ExoCarta_22785
Entrez Gene 22785
UniProt O35149  
 Slc30a4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Slc30a4
Molecular Function
    cation transmembrane transporter activity GO:0008324 IEA
    zinc ion transmembrane transporter activity GO:0005385 ISO
Biological Process
    zinc ion homeostasis GO:0055069 IMP
    regulation of sequestering of zinc ion GO:0061088 ISO
    cation transport GO:0006812 IEA
    zinc II ion transport GO:0006829 IEA
    ion transport GO:0006811 IEA
    response to toxic substance GO:0009636 ISO
    transport GO:0006810 IEA
    zinc II ion transmembrane transport GO:0071577 ISO
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    endosome GO:0005768 IEA
    late endosome GO:0005770 ISO
    cytoplasm GO:0005737 ISO
    integral component of membrane GO:0016021 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Slc30a4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Slc30a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc30a4 is involved
No pathways found





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