Gene description for Slc30a4
Gene name solute carrier family 30 (zinc transporter), member 4
Gene symbol Slc30a4
Other names/aliases Znt4
lm
znT-4
Species Mus musculus
 Database cross references - Slc30a4
ExoCarta ExoCarta_22785
Vesiclepedia VP_22785
Entrez Gene 22785
UniProt O35149  
 Slc30a4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Slc30a4
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 ISO
    antiporter activity GO:0015297 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    response to toxic substance GO:0009636 IEA
    response to toxic substance GO:0009636 ISO
    response to zinc ion GO:0010043 IBA
    zinc ion transmembrane transport GO:0071577 IBA
    zinc ion transmembrane transport GO:0071577 IDA
    zinc ion transmembrane transport GO:0071577 ISO
    zinc export across plasma membrane GO:0140882 IMP
    zinc ion import into lysosome GO:0140916 IEA
    zinc ion import into lysosome GO:0140916 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    lysosomal membrane GO:0005765 IEA
    late endosome GO:0005770 ISO
    plasma membrane GO:0005886 IBA
    endosome membrane GO:0010008 ISO
    endosome membrane GO:0010008 ISS
    late endosome membrane GO:0031902 IEA
 Experiment description of studies that identified Slc30a4 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Slc30a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc30a4 is involved
No pathways found





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